Document Detail


L-Arginine in pregnant scleroderma patients.
MedLine Citation:
PMID:  20213128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic sclerosis (SSc) pregnant women show a high frequency of premature births and occurrence of renal crisis. Some evidences showed the role of L-arginine in the prevention and treatment of preeclampsia. Here, we report our experience on the effect of L-arginine treatment in four consecutive SSc pregnant women. Two patients, who have planned the pregnancy, were treated with oral L-arginine; both delivered healthy babies without any prenatal complications. The other two, with high risk of pregnancy complications because of severe lung involvement and type 1 diabetes, respectively, underwent i.v. L-arginine: patient 3 had a premature delivery of a 2-kg healthy baby, while patient 4 developed preeclampsia and, at the 28th week, delivered a 1,050-g girl. The neonate had severe respiratory distress syndrome complicated by severe infection and died at day 28. Although limited, our pilot study suggests that L-arginine may be a useful therapeutic agent in pregnant SSc women.
Authors:
Dilia Giuggioli; Michele Colaci; Marco Sebastiani; Clodoveo Ferri
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-03-06
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  937-9     Citation Subset:  IM    
Affiliation:
Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy. giuggioli.dilia@policlinico.mo.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Arginine / administration & dosage,  adverse effects,  therapeutic use*
Female
Humans
Infant, Newborn
Injections, Intravenous
Pilot Projects
Pre-Eclampsia / prevention & control*
Pregnancy
Pregnancy Complications / prevention & control*
Pregnancy Outcome
Scleroderma, Systemic / complications*
Chemical
Reg. No./Substance:
74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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