| L-Arginine in pregnant scleroderma patients. | |
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MedLine Citation:
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PMID: 20213128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic sclerosis (SSc) pregnant women show a high frequency of premature births and occurrence of renal crisis. Some evidences showed the role of L-arginine in the prevention and treatment of preeclampsia. Here, we report our experience on the effect of L-arginine treatment in four consecutive SSc pregnant women. Two patients, who have planned the pregnancy, were treated with oral L-arginine; both delivered healthy babies without any prenatal complications. The other two, with high risk of pregnancy complications because of severe lung involvement and type 1 diabetes, respectively, underwent i.v. L-arginine: patient 3 had a premature delivery of a 2-kg healthy baby, while patient 4 developed preeclampsia and, at the 28th week, delivered a 1,050-g girl. The neonate had severe respiratory distress syndrome complicated by severe infection and died at day 28. Although limited, our pilot study suggests that L-arginine may be a useful therapeutic agent in pregnant SSc women. |
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Authors:
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Dilia Giuggioli; Michele Colaci; Marco Sebastiani; Clodoveo Ferri |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-03-06 |
Journal Detail:
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Title: Clinical rheumatology Volume: 29 ISSN: 1434-9949 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Germany |
Other Details:
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Languages: eng Pagination: 937-9 Citation Subset: IM |
Affiliation:
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Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy. giuggioli.dilia@policlinico.mo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Arginine / administration & dosage, adverse effects, therapeutic use* Female Humans Infant, Newborn Injections, Intravenous Pilot Projects Pre-Eclampsia / prevention & control* Pregnancy Pregnancy Complications / prevention & control* Pregnancy Outcome Scleroderma, Systemic / complications* |
| Chemical | |
Reg. No./Substance:
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74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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