Document Detail

L-Arginine attenuates xanthine oxidase and myeloperoxidase activities in hearts of rats during exhaustive exercise.
MedLine Citation:
PMID:  16441918     Owner:  NLM     Status:  MEDLINE    
The present study was to investigate the effects of l-arginine (l-Arg) supplementation on cardiac oxidative stress and the inflammatory response in rats following acute exhaustive exercise on a treadmill. Rats were randomly divided into four groups: sedentary control (SC); SC with l-Arg treatment (SC+Arg); exhaustive exercise (E); exhaustive exercise with l-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2 % l-Arg diet. Rats in groups E and E+Arg performed an exhaustive running test on a treadmill at a final speed of 30 m/min, 10 % grade, at approximately 70-75 % VO2max. The results showed a significant increase in cardiac xanthine oxidase (XO) and myeloperoxidase activities and membrane lipid peroxidation endproduct (malondialdehyde; MDA) levels of exercised rats compared with SC rats. The increased cardiac XO activity and MDA levels in exercised rats were significantly decreased in exercised rats supplemented with l-Arg. Myocardial GSSG content increased whereas the GSH:GSSG ratio was depressed in exercised rats compared with SC rats. Cardiac GSSG levels significantly decreased, whereas total glutathione, GSH and the GSH:GSSG ratio increased in exercised rats supplemented with l-Arg compared with exercised rats. The activities of creatinine kinase (CK) and lactate dehydrogenase (LDH), and lactate, uric acid, and nitrite and nitrate levels in the plasma significantly increased in exercised rats compared with SC rats. The activities of plasma CK and LDH were significantly decreased in l-Arg-supplemented plus exercised rats compared with exercised rats. These findings suggest that l-Arg supplementation reduces the oxidative damage and inflammatory response on the myocardium caused by exhaustive exercise in rats.
Wan-Teng Lin; Suh-Ching Yang; Shiow-Chwen Tsai; Chi-Chang Huang; Ning-Yuean Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  95     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-75     Citation Subset:  IM    
De Lin Institute of Technology, Taipei, Taiwan, Republic of China.
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MeSH Terms
Antioxidants / metabolism
Arginine / administration & dosage,  pharmacology*
Blood Chemical Analysis / methods
Body Weight / physiology
Dietary Supplements*
Glutathione / metabolism
Lipid Peroxidation / physiology
Myocardium / enzymology*
Oxidative Stress / physiology
Peroxidase / metabolism*
Physical Conditioning, Animal / methods*
Physical Endurance / physiology
Rats, Sprague-Dawley
Xanthine Oxidase / metabolism*
Reg. No./Substance:
0/Antioxidants; 70-18-8/Glutathione; 74-79-3/Arginine; EC; EC Oxidase

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