| L-arginine and antioxidant vitamins E and C improve the cardiovascular performance of broiler chickens grown under chronic hypobaric hypoxia. | |
| | |
MedLine Citation:
|
PMID: 20852105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two hundred broiler chicks were randomly assigned to 3 dietary treatments: control [CTL; 3,200 kcal of ME/kg, 23% CP, 1.55% Arg, and 40 IU of vitamin E (VE)/kg of feed], high-Arg (HA; CTL+0.8% Arg), or high-Arg and high antioxidant-vitamin diet (AEC; HA+200 IU of VE/kg of feed and 500 mg of vitamin C/L of water). The chicks were housed in wire cages in hypobaric chambers simulating 3,000 m above sea level. From d 28 to 42, clinically healthy birds were selected for cardiovascular performance (n=7 to 12/treatment). After surgery, pulmonary arterial pressure (PAP) and mean arterial pressure (MAP) readings were taken at 180, 120, and 60 s (basal values) before an epinephrine (EPI) challenge and then at 30, 60, 120, 180, 300, 600, and 1,200 s after the challenge, followed by a second EPI challenge with similar sample readings. There were no differences in the basal PAP values among chicken groups. The PAP increased within 30 s after both EPI challenges in all groups. It took 180 s after the first EPI challenge for the CTL chickens to return to the basal PAP values, whereas HA and AEC chickens returned to basal PAP values in 120 s. After the second EPI challenge, it took 60, 180, and 300 s for the AEC, HA, and CTL groups, respectively, to return to basal PAP values. The MAP response pattern to the EPI challenges mimicked that of PAP, but there were no differences among treatments in MAP at any sampling point. Supplemental Arg, VE, and vitamin C did not reduce ascites incidence in hypoxic broilers. In conclusion, supplemental Arg improved the pulmonary vascular performance of hypoxic broiler chickens and its effects were further improved by the addition of the antioxidant VE and vitamin C. Arginine and antioxidant vitamins may have played synergistic roles to increase NO bioavailability and reduce oxidative stress damage, thus improving cardiopulmonary performance. |
| | |
Authors:
|
J Bautista-Ortega; C A Ruiz-Feria |
Related Documents
:
|
6878135 - The effect of saturation, chain length of pure triglycerides, and age of bird on the ut... 2741305 - Effects of arsanilic acid and monensin when given simultaneously in the diet of broiler... 18212375 - Apparent metabolizable energy of glycerin for broiler chickens. 8614685 - Developmental stability in relation to population density and breed of chickens gallus ... 12532155 - Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat... 20538045 - Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Poultry science Volume: 89 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-20 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 2141-6 Citation Subset: IM |
Affiliation:
|
Department of Poultry Science, Texas A&M University, College Station 77843-2472, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animal Feed Animal Nutritional Physiological Phenomena Animals Anoxia / blood* Arginine / pharmacology* Ascorbic Acid / pharmacology* Cardiovascular Diseases / prevention & control, veterinary* Diet / veterinary Dietary Supplements* Poultry Diseases / prevention & control Pressure Time Factors Vitamin E / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Salmonella antibiotic-mutant strains reduce fecal shedding and organ invasion in broiler chicks.
Next Document: Comparison of hydrated sodium calcium aluminosilicate and yeast cell wall on counteracting aflatoxic...