Document Detail

L-Arginine, ADMA, SDMA, creatinine, MDRD formula: detour to renal function testing.
MedLine Citation:
PMID:  19034882     Owner:  NLM     Status:  MEDLINE    
We report the case of a 50-year-old woman in whom a laboratory work-up for a suspected L-arginine deficiency and the concomitant determination of elevated symmetrical dimethylarginine (SDMA) led to a diagnosis of chronic kidney disease. This diagnosis had been missed due to the '';normal'' serum creatinine. This case illustrates that patients and physicians, while perusing non-evidence-based treatment strategies, such as L-arginine supplementation, fail to recognize the importance of evidence-based medicine, such as renal function testing. It also supports the notion that routine estimation of glomerular filtration rate should be mandatory in every patient for whom a serum creatinine test is ordered.
Jan T Kielstein; Jens Martens-Lobenhoffer; Stefan Vollmer; Stefanie M Bode-Böger
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nephrology     Volume:  21     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  959-61     Citation Subset:  IM    
Department of Nephrology, Medical School Hannover, Hannover - Germany.
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MeSH Terms
Arginine / analogs & derivatives*,  blood*,  therapeutic use
Biological Markers / blood
Diagnosis, Differential
Dietary Supplements
Glomerular Filtration Rate
Kidney Failure, Chronic / diagnosis,  diet therapy,  metabolism*
Middle Aged
Nitric Oxide Synthase / antagonists & inhibitors
Reg. No./Substance:
0/Biological Markers; 30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine; EC Oxide Synthase

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