Document Detail

L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver.
MedLine Citation:
PMID:  2354190     Owner:  NLM     Status:  MEDLINE    
L-Alanine: 4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells.
R Mamet; R Mevasser; Y Bomstein; A Atsmon; N Schoenfeld
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1034     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-23     Completed Date:  1990-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  148-51     Citation Subset:  IM    
Laboratory of Biochemical Pharmacology, Beilinson Medical Center, Petah Tiqva, Israel.
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MeSH Terms
Alanine / metabolism
Allylisopropylacetamide / pharmacology
Aminolevulinic Acid / metabolism
Chick Embryo
Dicarbethoxydihydrocollidine / pharmacology
Enzyme Induction / drug effects
Heme / biosynthesis*
Hemin / pharmacology
Liver / embryology,  enzymology*
Phenobarbital / pharmacology
Porphyrins / biosynthesis
Rats, Inbred Strains
Transaminases / metabolism*
Valerates / metabolism
Reg. No./Substance:
0/Porphyrins; 0/Valerates; 106-60-5/Aminolevulinic Acid; 14875-96-8/Heme; 16009-13-5/Hemin; 299-78-5/Allylisopropylacetamide; 50-06-6/Phenobarbital; 56-41-7/Alanine; 5976-90-9/4,5-dioxovaleric acid; 632-93-9/Dicarbethoxydihydrocollidine; EC 2.6.1.-/Transaminases; EC aminotransferase

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