| L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver. | |
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MedLine Citation:
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PMID: 2354190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-Alanine: 4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells. |
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Authors:
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R Mamet; R Mevasser; Y Bomstein; A Atsmon; N Schoenfeld |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1034 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-07-23 Completed Date: 1990-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 148-51 Citation Subset: IM |
Affiliation:
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Laboratory of Biochemical Pharmacology, Beilinson Medical Center, Petah Tiqva, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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metabolism Allylisopropylacetamide / pharmacology Aminolevulinic Acid / metabolism Animals Chick Embryo Dicarbethoxydihydrocollidine / pharmacology Enzyme Induction / drug effects Heme / biosynthesis* Hemin / pharmacology Liver / embryology, enzymology* Male Phenobarbital / pharmacology Porphyrins / biosynthesis Rats Rats, Inbred Strains Transaminases / metabolism* Valerates / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Porphyrins; 0/Valerates; 106-60-5/Aminolevulinic Acid; 14875-96-8/Heme; 16009-13-5/Hemin; 299-78-5/Allylisopropylacetamide; 50-06-6/Phenobarbital; 56-41-7/Alanine; 5976-90-9/4,5-dioxovaleric acid; 632-93-9/Dicarbethoxydihydrocollidine; EC 2.6.1.-/Transaminases; EC 2.6.1.43/aminolevulinate aminotransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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