Document Detail

L-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI.
MedLine Citation:
PMID:  16378695     Owner:  NLM     Status:  MEDLINE    
The objective of the study was to assess l-5-hydroxytryptophan's (l-5HTP) augmentation effect on the neuroendocrine response to a SSRI (citalopram). A neuroendocrine challenge study was conducted in healthy Asian male subjects. The neuroendocrine response to oral citalopram and l-5HTP was measured primarily as the prolactin and cortisol area under the response curve (or AUC). The study comprised 2 studies: Study 1. A double blind, randomised dose ranging study was conducted with l-5HTP (50-200 mg) to explore the prolactin and/or cortisol dose response and select a dose that provided a threshold neuroendocrine response. Study 2. A randomized comparison of citalopram 20 vs 40 mg was used to assess the effect of these doses on prolactin and cortisol. Based on the results of the dose response assessments with l-5HTP and cortisol, 200 mg l-5HTP was subsequently used in Study 2 to explore the augmentation of the neuroendocrine response to 20 mg citalopram. Citalopram, but not l-5HTP, increased prolactin AUC(0-3h) while 5HTP and citalopram increased cortisol AUC(0-3h). A 200 mg dose of l-5HTP significantly augmented the prolactin and cortisol response AUC(0-3h) to 20mg oral citalopram. The results of the study suggest that an augmented neuroendocrine challenge may be a suitable marker to demonstrate increased 5-HT-mediated responses when exploring novel agents as improved SSRIs.
Stephen L Lowe; Kwee Poo Yeo; Leyan Teng; Danny K W Soon; Alan Pan; Stephen D Wise; Richard W Peck
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-12-27
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  31     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  473-84     Citation Subset:  IM    
Lilly-NUS Centre for Clinical Pharmacology, Level 6, Clinical Research Centre (MD11), National University of Singapore, 10 Medical Drive, Singapore, Singapore 117597.
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MeSH Terms
5-Hydroxytryptophan / physiology*
Area Under Curve
Citalopram / pharmacology*
Dose-Response Relationship, Drug
Double-Blind Method
Hydrocortisone / blood*
Middle Aged
Neurosecretory Systems / drug effects
Prolactin / blood*,  drug effects
Reference Values
Serotonin Uptake Inhibitors / pharmacology*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 50-23-7/Hydrocortisone; 56-69-9/5-Hydroxytryptophan; 59729-33-8/Citalopram; 9002-62-4/Prolactin

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