Document Detail


Kynurenines in the mammalian brain: when physiology meets pathology.
MedLine Citation:
PMID:  22678511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The essential amino acid tryptophan is not only a precursor of serotonin but is also degraded to several other neuroactive compounds, including kynurenic acid, 3-hydroxykynurenine and quinolinic acid. The synthesis of these metabolites is regulated by an enzymatic cascade, known as the kynurenine pathway, that is tightly controlled by the immune system. Dysregulation of this pathway, resulting in hyper-or hypofunction of active metabolites, is associated with neurodegenerative and other neurological disorders, as well as with psychiatric diseases such as depression and schizophrenia. With recently developed pharmacological agents, it is now possible to restore metabolic equilibrium and envisage novel therapeutic interventions.
Authors:
Robert Schwarcz; John P Bruno; Paul J Muchowski; Hui-Qiu Wu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  13     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-08-29     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  465-77     Citation Subset:  IM    
Affiliation:
University of Maryland School of Medicine, Baltimore, Maryland 21228, USA. rschwarc@mprc. umaryland.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology*,  physiology*
Humans
Kynurenine / metabolism*
Nervous System Diseases / metabolism*,  pathology*
Signal Transduction / physiology*
Grant Support
ID/Acronym/Agency:
R01 MH083729/MH/NIMH NIH HHS; R01 NS057715/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
343-65-7/Kynurenine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Temperature-controlled phase-transfer catalysis for ethylene glycol production from cellulose.
Next Document:  Efficacy of Coopdech videolaryngoscope: comparisons with a Macintosh laryngoscope and the Airway Sco...