| Kynurenine inhibits chondrocyte proliferation and is increased in synovial fluid of patients with septic arthritis. | |
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MedLine Citation:
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PMID: 20872586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kynurenine, the major degradation product of tryptophan has been shown to directly damage various tissues. Its potential contribution to septic arthritis is unknown. In this study, we analyzed the putative diagnostic value of kynurenine for bacterial joint infection and its potential harmful effects on cartilage. In a prospective study 41 patients with a joint effusion who had undergone arthrocentesis were included. Tryptophan and kynurenine levels from synovial fluid were quantified by HPLC. Diagnostic value of kynurenine was evaluated and its effects on the proliferation of the chondrocyte cell line ATDC5 were determined. Synovial fluid kynurenine values from patients with septic arthritis (4.1 ± 0.8 µmol/L, n = 9) were significantly increased compared to patients with non-infectious inflammatory arthropathy (1.8 ± 0.2 µmol/L, n = 17) or osteoarthritis (1.2 ± 0.1 µmol/L, n = 15, p < 0.01). At a cut-off value of 2.28 µmol/L kynurenine had a sensitivity of 0.89 and a specificity of 0.87. Further, kynurenine inhibited chondrocyte (ATDC5) cell proliferation in a dose-dependent manner. Septic arthritis is associated with significantly increased values of synovial kynurenine. Furthermore kynurenine inhibits proliferation of chondrocytes, which strongly suggests a pathophysiological effect of kynurenine on cartilage in inflammatory arthropathies. |
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Authors:
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Tim T Lögters; Maurice D Laryea; Marcus Jäger; Michael Schädel-Höpfner; Joachim Windolf; Sascha Flohé; Jens Altrichter; Martin Scholz; Adnana N Paunel-Görgülü |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 28 ISSN: 1554-527X ISO Abbreviation: J. Orthop. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: United States |
Other Details:
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Languages: eng Pagination: 1490-6 Citation Subset: IM |
Copyright Information:
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© 2010 Orthopaedic Research Society. |
Affiliation:
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Department of Trauma and Hand Surgery, University Hospital Düsseldorf, Moorenstr 5, 40225 Düsseldorf, Germany. tim.loegters@uni-duesseldorf.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Arthritis, Infectious / metabolism*, microbiology C-Reactive Protein / analysis Cell Proliferation Cells, Cultured Chondrocytes / physiology* Female Humans Kynurenine / analysis, physiology* Male Middle Aged Prospective Studies ROC Curve Synovial Fluid / chemistry* Tryptophan / analysis |
| Chemical | |
Reg. No./Substance:
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343-65-7/Kynurenine; 73-22-3/Tryptophan; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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