| Kynurenic acid enhances expression of p21 Waf1/Cip1 in colon cancer HT-29 cells. | |
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MedLine Citation:
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PMID: 22814028 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Kynurenic acid (KYNA), a tryptophan metabolite, was found in the mucus of rat small intestine. However, its role in the gastrointestinal tract is still not fully elucidated. Methods: To verify whether KYNA affects cell cycle regulators, the protein expression of cyclin-dependent kinase inhibitor p21 Waf1/Cip1 was investigated in colon adenocarcinoma HT-29 cells exposed to KYNA. MTT, BrdU assay and siRNA technology were used to evaluate the effect of KYNA on cancer cell proliferation. Results: KYNA significantly enhanced the expression of p21 Waf1/Cip1. Importantly, the overexpression of this protein was involved in inhibition of proliferation and DNA synthesis in HT-29 cells. Conclusions: KYNA may be considered as a potential chemoprevention agent against colon cancer. |
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Authors:
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Katarzyna Walczak; Waldemar A Turski; Wojciech Rzeski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacological reports : PR Volume: 64 ISSN: 1734-1140 ISO Abbreviation: Pharmacol Rep Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234999 Medline TA: Pharmacol Rep Country: Poland |
Other Details:
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Languages: eng Pagination: 745-50 Citation Subset: IM |
Affiliation:
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Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, PL 20-950 Lublin, Poland. walczak.ka@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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