| Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms. | |
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MedLine Citation:
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PMID: 8198681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrospinal fluid (CSF) from 8 patients with symptomatic infantile spasms was collected before specific treatment for infantile spasms. The concentration of CSF kynurenic acid (KYA) and 3-hydroxykynurenine (3-OHKY) in infantile spasms was analyzed by high-performance liquid chromatography and compared with CSF KYA from 10 age-matched controls. The levels of CSF KYA were significantly lower in infantile spasm patients compared to controls (P < .05). In contrast, the levels of CSF 3-OHKY were significantly higher in infantile spasm patients than in controls (P < .05). These findings suggest that the presence of seizures in infantile spasms is associated with altered metabolism of 3-OHKY. The possibility that seizures may be related to increased or decreased production of certain kynurenine metabolites is discussed. |
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Authors:
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H Yamamoto; I Shindo; B Egawa; K Horiguchi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 10 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-07-06 Completed Date: 1994-07-06 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 9-12 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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cerebrospinal fluid,
diagnosis Brain / physiopathology Chromatography, High Pressure Liquid Electroencephalography Female Humans Infant Infant, Newborn Kynurenic Acid / cerebrospinal fluid* Kynurenine / analogs & derivatives, cerebrospinal fluid Male Spasms, Infantile / cerebrospinal fluid*, diagnosis Synaptic Transmission / physiology Tuberous Sclerosis / cerebrospinal fluid, diagnosis |
| Chemical | |
Reg. No./Substance:
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343-65-7/Kynurenine; 484-78-6/3-hydroxykynurenine; 492-27-3/Kynurenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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