Document Detail


Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms.
MedLine Citation:
PMID:  8198681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebrospinal fluid (CSF) from 8 patients with symptomatic infantile spasms was collected before specific treatment for infantile spasms. The concentration of CSF kynurenic acid (KYA) and 3-hydroxykynurenine (3-OHKY) in infantile spasms was analyzed by high-performance liquid chromatography and compared with CSF KYA from 10 age-matched controls. The levels of CSF KYA were significantly lower in infantile spasm patients compared to controls (P < .05). In contrast, the levels of CSF 3-OHKY were significantly higher in infantile spasm patients than in controls (P < .05). These findings suggest that the presence of seizures in infantile spasms is associated with altered metabolism of 3-OHKY. The possibility that seizures may be related to increased or decreased production of certain kynurenine metabolites is discussed.
Authors:
H Yamamoto; I Shindo; B Egawa; K Horiguchi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  10     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-07-06     Completed Date:  1994-07-06     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / cerebrospinal fluid,  diagnosis
Brain / physiopathology
Chromatography, High Pressure Liquid
Electroencephalography
Female
Humans
Infant
Infant, Newborn
Kynurenic Acid / cerebrospinal fluid*
Kynurenine / analogs & derivatives,  cerebrospinal fluid
Male
Spasms, Infantile / cerebrospinal fluid*,  diagnosis
Synaptic Transmission / physiology
Tuberous Sclerosis / cerebrospinal fluid,  diagnosis
Chemical
Reg. No./Substance:
343-65-7/Kynurenine; 484-78-6/3-hydroxykynurenine; 492-27-3/Kynurenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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