| Kurtosis and Skewness of Density Histograms on Inspiratory and Expiratory CT Scans in Smokers. | |
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MedLine Citation:
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PMID: 21299474 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this study is to evaluate the relationship between lung function and kurtosis or skewness of lung density histograms on computed tomography (CT) in smokers. Forty-six smokers (age range 46?81 years), enrolled in the Lung Tissue Research Consortium, underwent pulmonary function tests (PFT) and chest CT at full inspiration and full expiration. On both inspiratory and expiratory scans, kurtosis and skewness of the density histograms were automatically measured by open-source software. Correlations between CT measurements and lung function were evaluated by the linear regression analysis. Although no significant correlations were found between inspiratory kurtosis or skewness and PFT results, expiratory kurtosis significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV(1)), the ratio of FEV(1) to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV(1)%predicted, R = ?0.581, p < 0.001; FEV(1)/FVC, R = ?0.612, p < 0.001; RV/TLC, R = 0.613, p < 0.001, respectively). Similarly, expiratory skewness showed significant correlations with PFT results (FEV(1)%predicted, R = ?0.584, p < 0.001; FEV(1)/FVC, R = ?0.619, p < 0.001; RV/TLC, R = 0.585, p < 0.001, respectively). Also, the expiratory/inspiratory (E/I) ratios of kurtosis and skewness significantly correlated with FEV(1)%predicted (p < 0.001), FEV(1)/FVC (p < 0.001), RV/TLC (p < 0.001), and the percentage of predicted value of diffusing capacity for carbon monoxide (kurtosis E/I ratio, p = 0.001; skewness E/I ratio, p = 0.03, respectively). We conclude therefore that expiratory values and the E/I ratios of kurtosis and skewness of CT densitometry reflect airflow limitation and air-trapping. Higher kurtosis or skewness on expiratory CT scan indicates more severe conditions in smokers. |
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Authors:
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Tsuneo Yamashiro; Shin Matsuoka; Ra L San Jos Est Par; Brian J Bartholmai; Alejandro Diaz; James C Ross; Sadayuki Murayama; Edwin K Silverman; Hiroto Hatabu; George R Washko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: COPD Volume: 8 ISSN: 1541-2563 ISO Abbreviation: COPD Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101211769 Medline TA: COPD Country: England |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Boston, MA, USA,1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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