| Kounis syndrome associated with hypersensitivity to hymenoptera stings. | |
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MedLine Citation:
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PMID: 16647768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hymenoptera stings can induce acute coronary syndromes by different pathogenetic mechanisms including direct action of the venom constituents on the coronary endothelium or allergic reaction with mediators acting on the coronary vasculature. Two patients were stung by wasps and honeybees and developed Kounis syndrome as a consequence of allergic reaction. Kounis syndrome is the concurrence of acute coronary syndromes with mast cell activation induced by allergic or hypersensitivity and anaphylactic of anaphylactoid reactions. It is caused via inflammatory mediators released through mast cell activation. The patients had pre-existing coronary artery disease (type II variant of Kounis syndrome) and the allergic reaction induced by hymenoptera stings seems to have triggered inflammatory mediator release. The pathophysiology and clinical implications of this association are discussed. |
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Authors:
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John S Kogias; Skevos K Sideris; Sotirios K Anifadis |
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Publication Detail:
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Type: Case Reports; Letter Date: 2006-05-02 |
Journal Detail:
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Title: International journal of cardiology Volume: 114 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-01-25 Revised Date: 2007-02-22 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 252-5 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina, Unstable / immunology* Animals Bees* Bites and Stings / complications*, immunology* Humans Male Mast Cells / immunology* Middle Aged Myocardial Infarction / immunology* Syndrome Wasps* |
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