Document Detail

Kounis syndrome.
MedLine Citation:
PMID:  20926990     Owner:  NLM     Status:  MEDLINE    
The association between acute coronary events and acute allergic reactions has been recognized for several years. The first reported case occurred in 1950, during an allergic reaction to penicillin. In 1991, Kounis and Zavras described the syndrome of allergic angina and allergic myocardial infarction, currently known as Kounis syndrome. Two subtypes have been described: type I, which occurs in patients without predisposing factors for coronary artery disease and is caused by coronary artery spasm, and type II, which occurs in patients with angiographic evidence of coronary disease when the allergic events induce plaque erosion or rupture. This syndrome has been reported in association with a variety of medical conditions, environmental exposures, and medication exposures. Entities such as Takotsubo cardiomyopathy, drug-eluted stent thrombosis, and coronary allograft vasculopathy appear to be associated with this syndrome. In this review, we discuss the pathobiology, clinical features, associated entities, and management of Kounis syndrome.
Pablo R Lopez; Alan N Peiris
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  103     ISSN:  1541-8243     ISO Abbreviation:  South. Med. J.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1148-55     Citation Subset:  AIM; IM    
Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, and Mountain Home Veterans Affairs Medical Center, Johnson City, TN 37416-1709, USA.
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MeSH Terms
Acute Coronary Syndrome* / diagnosis,  immunology,  therapy
Hypersensitivity* / diagnosis,  etiology,  therapy

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