| Kounis syndrome or allergic coronary vasospasm in a two-year-old. | |
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MedLine Citation:
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PMID: 21418536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kounis syndrome is coronary vasospasm because of mast cell degranulation in the context of an allergic reaction. The syndrome has known associations with several drugs used during anesthesia, including rocuronium and isoflurane. In this case report, we discuss a 2-year-old patient who developed signs and symptoms of an acute coronary syndrome soon after anesthesia for atrial septal defect repair. A diagnostic angiography after the episode revealed diffusely small coronary arteries. Subsequent angiography after clinical improvement showed essentially normal coronary anatomy. We report the clinical course of this patient and postulate that Kounis syndrome was the explanation for his transient coronary vasospasm. To date, this is the youngest known patient with reported Kounis syndrome. |
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Authors:
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Brodie Parent; Peter Wearden; Nicholas G Kounis; Constantinos Chrysostomou |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2011-03-21 |
Journal Detail:
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Title: Congenital heart disease Volume: 6 ISSN: 1747-0803 ISO Abbreviation: Congenit Heart Dis Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-09-14 Completed Date: 2012-01-13 Revised Date: 2012-01-18 |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 499-503 Citation Subset: IM |
Copyright Information:
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© 2011 Copyright the Authors. Congenital Heart Disease © 2011 Wiley Periodicals, Inc. |
Affiliation:
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University of Pittsburgh, School of Medicine, Children's Hospital of Pittsburgh of UPMC, 45th and Penn Avenue, Pittsburgh, PA 15201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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diagnosis*,
etiology,
therapy Androstanols / adverse effects* Anesthesia, General / adverse effects* Anesthetics, Inhalation / adverse effects* Cardiac Surgical Procedures Child, Preschool Coronary Angiography Coronary Vasospasm / diagnosis*, etiology, therapy Electrocardiography Heart Septal Defects, Atrial / surgery Humans Hypersensitivity / diagnosis*, etiology, therapy Isoflurane / adverse effects* Male Neuromuscular Nondepolarizing Agents / adverse effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Androstanols; 0/Anesthetics, Inhalation; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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