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Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties.
MedLine Citation:
PMID:  20934336     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This study was conducted to examine the tyrosinase inhibitory and anti-inflammatory activities of kojic acid derivatives. A series of kojic acid derivatives containing thioether, sulfoxide, and sulfone linkages were synthesized. In the tyrosinase assay, kojyl thioether derivatives containing appropriate lipophilic alkyl chains (pentane, hexane, and cyclohexane) showed potent inhibitory activity. However, sulfoxides and sulfones exhibited decreased activity. Similar experimental results were obtained with inhibitory activities of NO production being induced by LPS. The presence of thioether linkage and appropriated lipophilic acid moiety was critical for the tyrosinase inhibitory and anti-inflammatory activities.
Authors:
Ho Sik Rho; Soo Mi Ahn; Dae Sung Yoo; Myung Kyoo Kim; Dong Ha Cho; Jae Youl Cho
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Publication Detail:
Type:  Journal Article     Date:  2010-09-21
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  6569-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
R & D Center, AmorePacific Corporation, Yongin 446-729, Republic of Korea. thiocarbon@freechal.com
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