| Kojic acid production by Aspergillus flavus using gelatinized and hydrolyzed sago starch as carbon sources. | |
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MedLine Citation:
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PMID: 9867479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Direct conversion of gelatinized sago starch into kojic acid by Aspergillus flavus strain having amylolytic enzymes was carried out at two different scales of submerged batch fermentation in a 250-mL shake flask and in a 50-L stirred-tank fermentor. For comparison, fermentations were also carried out using glucose and glucose hydrolyzate from enzymic hydrolysis of sago starch as carbon sources. During kojic acid fermentation of starch, starch was first hydrolyzed to glucose by the action of alpha-amylase and glucoamylase during active growth phase. The glucose remaining during the production phase (non-growing phase) was then converted to kojic acid. Kojic acid production (23.5 g/L) using 100 g/L sago starch in a shake flask was comparable to fermentation of glucose (31.5 g/L) and glucose hydrolyzate (27.9 g/L) but in the 50-L fermentor was greatly reduced due to non-optimal aeration conditions. Kojic acid production using glucose was higher in the 50-L fermentor than in the shake flask. |
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Authors:
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M Rosfarizan; A B Ariff; M A Hassan; M I Karim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia microbiologica Volume: 43 ISSN: 0015-5632 ISO Abbreviation: Folia Microbiol. (Praha) Publication Date: 1998 |
Date Detail:
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Created Date: 1998-12-11 Completed Date: 1998-12-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376757 Medline TA: Folia Microbiol (Praha) Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 459-64 Citation Subset: IM |
Affiliation:
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Department of Biotechnology, Universiti Putra Malaysia, Selangor. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillus flavus
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growth & development,
metabolism* Fermentation Glucan 1,4-alpha-Glucosidase / metabolism Glucose / metabolism Hydrolysis Mycotoxins / biosynthesis* Pyrones / metabolism* Starch / metabolism* alpha-Amylases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Mycotoxins; 0/Pyrones; 50-99-7/Glucose; 501-30-4/kojic acid; 9005-25-8/Starch; EC 3.2.1.1/alpha-Amylases; EC 3.2.1.3/Glucan 1,4-alpha-Glucosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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