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Kojic acid-amino acid amide metal complexes and their melanogenesis inhibitory activities.
MedLine Citation:
PMID:  21957050     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tyrosinase plays a critical role in the early stages of the melanin synthetic pathway by catalyzing the oxidation of the substrate. Therefore, tyrosinase inhibitors have been intensively studied in both cosmetic and food industries to develop hypopigmentary agents and prevent enzymatic browning in food. Previously, we reported that kojic acid-amino acid amide (KA-AA-NH(2) ) showed enhanced tyrosinase inhibitory activity compared with kojic acid alone, but this was not observed in a cell test because of poor cell permeability. To enhance cell permeability, we prepared copper and zinc complexes of KA-AA-NH(2) and characterized them using FT-IR spectroscopy, ESI-MS spectrometry, and inductively coupled plasma analysis. We then showed that KA-AA-NH(2) copper complexes exhibited melanogenesis inhibitory activity in Mel-Ab cells. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.
Authors:
Seon-Yeong Kwak; Hye-Ryung Choi; Kyoung-Chan Park; Yoon-Sik Lee
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-29
Journal Detail:
Title:  Journal of peptide science : an official publication of the European Peptide Society     Volume:  -     ISSN:  1099-1387     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506309     Medline TA:  J Pept Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.
Affiliation:
School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea.
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