Document Detail


Knowledge gaps in risk assessment of nanosilica in food: evaluation of the dissolution and toxicity of different forms of silica.
MedLine Citation:
PMID:  22394279     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract This manuscript describes the follow-up study of our previous publication on the presence and risks of nanosilica in food. New information on the presence of nanosilica in the gastrointestinal tract is evaluated and information on nanosilica and Synthetic Amorphous Silica (SAS) is compared to asses its relevance for risk assessment of nanosilica in food. Irrespective if SAS should be regarded as a nanomaterial or a non-nanoform of silica, a comparison to nanosilica is relevant to determine if there are differences in physicochemical properties which may lead to differences in toxicity. Based on this comparison knowledge gaps are identified and recommendations for a targeted approach to facilitate risk assessment of nanosilica in food are given. Considering the discussion to which extent nanomaterials with (slightly) different physicochemical characteristics can be grouped for risk assessment - the sameness issue - actual exercises as presented in this manuscript are highly relevant for bringing this discussion forward.
Authors:
Susan Dekkers; Hans Bouwmeester; Peter Bos; Ruud Peters; Anton Rietveld; Agnes Oomen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-7
Journal Detail:
Title:  Nanotoxicology     Volume:  -     ISSN:  1743-5404     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233132     Medline TA:  Nanotoxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
RIVM - National Institute for Public Health and the Environment , PO Box, 3720 BA Bilthoven , The Netherlands.
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