Document Detail


Knowledge-based generation of diagnostic hypotheses and therapy recommendations for toxoplasma infections in pregnancy.
MedLine Citation:
PMID:  17701826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary infection of pregnant women with the parasite Toxoplasma gondii results in infections of the unborn by transplacental transmission in about 50% of the cases. The degree of possible damage depends on the duration of parasitical impact on fetal tissues. The web-based software system ToxoNet processes the results of serological antibody tests performed during pregnancy by means of a knowledge base containing medical knowledge on the interpretation of toxoplasmosis serology findings. For this purpose, it matches the results of all serological investigations of maternal blood with the content of the knowledge base and generates interpretive reports consisting of a diagnostic hypothesis, recommendations for therapy, and proposals for further investigations. Fuzzy sets are used to formalize certain intervals between subsequent investigations to take the varying immune responses of individual patients into account. In a retrospective study, ToxoNet classified 100% of the trivial serological cases and about 87.8% of the more complex cases correctly. ToxoNet comprises a knowledge base, a system for interpretation, and a knowledge acquisition and modification program. It is available on the WWW by accessing a medical knowledge-base server via standard browsers.
Authors:
Dieter Kopecky; Klaus-Peter Adlassnig; Andrea-Romana Prusa; Michael Hayde; Yoichi Hayashi; Birgit Panzenböck; Andrea Rappelsberger; Arnold Pollak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical informatics and the Internet in medicine     Volume:  32     ISSN:  1463-9238     ISO Abbreviation:  Med Inform Internet Med     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100883495     Medline TA:  Med Inform Internet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-214     Citation Subset:  IM    
Affiliation:
Section on Medical Expert and Knowledge-Based Systems, Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Antibodies, Protozoan / blood
Decision Making, Computer-Assisted
Decision Support Systems, Clinical
Female
Fuzzy Logic
Humans
Infectious Disease Transmission, Vertical*
Internet
Knowledge Bases
Pregnancy
Pregnancy Complications, Infectious* / diagnosis,  therapy
Serologic Tests / methods
Toxoplasma
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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