Document Detail


Knowledge-based approach towards hydrolytic degradation of polymer-based biomaterials.
MedLine Citation:
PMID:  20882494     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The concept of hydrolytically degradable biomaterials was developed to enable the design of temporary implants that substitute or fulfill a certain function as long as required to support (wound) healing processes or to control the release of drugs. Examples are surgical implants, e.g., sutures, or implantable drug depots for treatment of cancer. In both cases degradability can help to avoid a second surgical procedure for explanation. Although degradable surgical sutures are established in the clinical practice for more than 30 years, still more than 40% of surgical sutures applied in clinics today are nondegradable.1 A major limitation of the established degradable suture materials is the fact that their degradation behavior cannot reliably be predicted by applying existing experimental methodologies. Similar concerns also apply to other degradable implants. Therefore, a knowledge-based approach is clearly needed to overcome the described problems and to enable the tailored design of biodegradable polymer materials. In this Progress Report we describe two methods (as examples for tools for this fundamental approach): molecular modeling combining atomistic bulk interface models with quantum chemical studies and experimental investigations of macromolecule degradation in monolayers on Langmuir-Blodgett (LB) troughs. Finally, an outlook on related future research strategies is provided.
Authors:
Dieter Hofmann; Maria Entrialgo-Castaño; Karl Kratz; Andreas Lendlein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advanced materials (Deerfield Beach, Fla.)     Volume:  21     ISSN:  1521-4095     ISO Abbreviation:  Adv. Mater. Weinheim     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9885358     Medline TA:  Adv Mater     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3237-45     Citation Subset:  -    
Affiliation:
Center for Biomaterial Development, Institute of Polymer Research, Teltow, Germany.
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