Document Detail


Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses.
MedLine Citation:
PMID:  23147708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The innate immune system is present in all animals and is a crucial first line of defence against pathogens. However, animals also harbour large numbers of beneficial microorganisms that can be housed in the digestive tract, in specialized organs or on tissue surfaces. Although invertebrates lack conventional antibody-based immunity, they are capable of eliminating pathogens and, perhaps more importantly, discriminating them from other microorganisms. This Review examines the interactions between the innate immune systems of several model invertebrates and the symbionts of these organisms, and addresses the central question of how these long-lived and specific associations are established and maintained.
Authors:
Spencer V Nyholm; Joerg Graf
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-11-13
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  10     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-02-07     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  815-27     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / immunology*
Humans
Immunity, Innate / immunology*
Invertebrates / immunology*,  microbiology*
Symbiosis / immunology
Grant Support
ID/Acronym/Agency:
R01 GM095390/GM/NIGMS NIH HHS; R01 GM095390/GM/NIGMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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