| Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses. | |
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MedLine Citation:
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PMID: 23147708 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The innate immune system is present in all animals and is a crucial first line of defence against pathogens. However, animals also harbour large numbers of beneficial microorganisms that can be housed in the digestive tract, in specialized organs or on tissue surfaces. Although invertebrates lack conventional antibody-based immunity, they are capable of eliminating pathogens and, perhaps more importantly, discriminating them from other microorganisms. This Review examines the interactions between the innate immune systems of several model invertebrates and the symbionts of these organisms, and addresses the central question of how these long-lived and specific associations are established and maintained. |
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Authors:
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Spencer V Nyholm; Joerg Graf |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-13 |
Journal Detail:
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Title: Nature reviews. Microbiology Volume: - ISSN: 1740-1534 ISO Abbreviation: Nat. Rev. Microbiol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101190261 Medline TA: Nat Rev Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269, USA. e-mails: spencer.nyholm@uconn.edu; joerg.graf@uconn.edu. |
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