| Knockout of the Na, K-ATPase {alpha}2-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension. | |
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MedLine Citation:
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PMID: 21856916 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The α2 isoform of the Na, K-ATPase (α2) is thought to play a role in blood pressure regulation, but the specific cell type(s) involved have not been identified. Therefore, it is important to study the role of the α2 in individual cell types in the cardiovascular system. The present study demonstrates the role of vascular smooth muscle α2 in the regulation of cardiovascular hemodynamics. To accomplish this, we developed a mouse model utilizing the Cre/LoxP system to generate a cell type specific knockout of the α2 in vascular smooth muscle cells using the SM22α Cre. We achieved a 90% reduction in the α2 expression in heart and vascular smooth muscle in the knockout mice. Interestingly, tail-cuff blood pressure analysis reveals that basal systolic blood pressure is unaffected by the knockout of α2 in the knockout mice. However, knockout mice do fail to develop ACTH-induced hypertension, as seen in wild type mice, following five days of treatment with ACTH (Cortrosyn®) (WT = 119.0 ± 6.8 mmHg, Knockout = 103.0 ± 2.0 mmHg). These results demonstrate that α2 expression in heart and vascular smooth muscle are not essential for regulation of basal systolic blood pressure, but α2 is critical for blood pressure regulation under chronic stress such as ACTH-induced hypertension. |
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Authors:
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Tara N Rindler; Iva Dostanic-Larson; Valerie M Lasko; Michelle L Nieman; Jonathan C Neumann; John N Lorenz; Jerry B Lingrel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Cincinnati. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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