Document Detail

Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis.
MedLine Citation:
PMID:  22246869     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: In this study we address the challenging issue of potential use of muscle strength to predict function in clinical trials. This has immediate relevance to translational studies that attempt to improve quadriceps strength in sporadic inclusion-body myositis (sIBM).
METHODS: Maximum voluntary isometric contraction testing as a measure of muscle strength and a battery of functional outcomes were tested in 85 ambulatory subjects with sIBM.
RESULTS: Marked quadriceps weakness was noted in all patients. Strength was correlated with distance walked at 2 and 6 minutes. Additional correlations were found with time to get up from a chair, climb stairs, and step up on curbs.
CONCLUSIONS: Quadriceps (knee extensor) strength correlated with performance in this large cohort of sIBM subjects, which demonstrated its potential to predict function in this disease. These data provide initial support for use of muscle strength as a surrogate for function, although validation in a clinical trial is required.
Linda Pax Lowes; Lindsay Alfano; Laurence Viollet; Xiomara Quintero Rosales; Zarife Sahenk; Brian K Kaspar; K Reed Clark; Kevin M Flanigan; Jerry R Mendell; Michael P McDermott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  45     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-02-29     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Aged, 80 and over
Functional Laterality
Isometric Contraction / physiology
Knee Joint / physiopathology*
Middle Aged
Muscle Strength / physiology*
Myositis, Inclusion Body / pathology*,  physiopathology*
Predictive Value of Tests
Psychomotor Performance / physiology
Quadriceps Muscle / physiopathology*
Walking / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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