| Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis. | |
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MedLine Citation:
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PMID: 22246869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: In this study we address the challenging issue of potential use of muscle strength to predict function in clinical trials. This has immediate relevance to translational studies that attempt to improve quadriceps strength in sporadic inclusion-body myositis (sIBM). METHODS: Maximum voluntary isometric contraction testing as a measure of muscle strength and a battery of functional outcomes were tested in 85 ambulatory subjects with sIBM. RESULTS: Marked quadriceps weakness was noted in all patients. Strength was correlated with distance walked at 2 and 6 minutes. Additional correlations were found with time to get up from a chair, climb stairs, and step up on curbs. CONCLUSIONS: Quadriceps (knee extensor) strength correlated with performance in this large cohort of sIBM subjects, which demonstrated its potential to predict function in this disease. These data provide initial support for use of muscle strength as a surrogate for function, although validation in a clinical trial is required. |
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Authors:
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Linda Pax Lowes; Lindsay Alfano; Laurence Viollet; Xiomara Quintero Rosales; Zarife Sahenk; Brian K Kaspar; K Reed Clark; Kevin M Flanigan; Jerry R Mendell; Michael P McDermott |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 45 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: 2012-02-29 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 163-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Center for Gene Therapy, Nationwide Children's Hospital, 700 Children's Drive, Columbus, Ohio 43205, USA. linda.lowes@nationwidechildrens.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Functional Laterality Humans Isometric Contraction / physiology Knee Joint / physiopathology* Male Middle Aged Muscle Strength / physiology* Myositis, Inclusion Body / pathology*, physiopathology* Predictive Value of Tests Psychomotor Performance / physiology Quadriceps Muscle / physiopathology* Walking / physiology |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR025755/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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