Document Detail

Knee extensor fatigability after bedrest for 8 weeks with and without countermeasure.
MedLine Citation:
PMID:  17661376     Owner:  NLM     Status:  MEDLINE    
We analyzed the effects of gravitational unloading on muscular fatigability and the effectiveness of resistive vibration exercise to counteract these changes. Changes in knee extensor fatigability as a consequence of 8 weeks of horizontal bedrest with or without daily resistive vibration exercise were evaluated in 17 healthy male volunteers. Bedrest increased fatigability (% decrease in maximal voluntary isometric torque per minute exercise) from -7.2 +/- 0.5 to -10.2 +/- 1.0%/min (P < 0.05), which was accompanied by a decline (of 52.0 +/- 3.7%, P < 0.05) in muscle blood flow. Daily resistive vibration exercise training during bedrest prevented increases in fatigability (from -10.8 +/- 1.8 to -8.4 +/- 1.6%/min, P < 0.05), and mitigated the reduction in blood flow (decline of 26.1 +/- 5.1%, P < 0.05). Daily resistive exercise may thus be suggested as an effective countermeasure during spaceflight and illness-related prolonged bedrest to combat the detrimental changes in muscle endurance that result from gravitational unloading.
Edwin R Mulder; Wolfgang M Kuebler; Karin H L Gerrits; Joern Rittweger; Dieter Felsenberg; Dick F Stegeman; Arnold de Haan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  36     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  798-806     Citation Subset:  IM    
Radboud University Nijmegen Medical Center, Department of Clinical Neurophysiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
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MeSH Terms
Bed Rest / adverse effects*
Blood Flow Velocity
Exercise Therapy / methods*
Exercise Tolerance
Knee / physiopathology
Muscle Contraction
Muscle Fatigue*
Muscle Weakness / etiology,  physiopathology*,  prevention & control
Muscular Disorders, Atrophic / etiology,  physiopathology*,  prevention & control
Physical Fitness
Quadriceps Muscle / blood supply,  physiopathology*
Spectroscopy, Near-Infrared
Time Factors
Treatment Outcome
Vibration / therapeutic use

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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