Document Detail


Klotho: an antiaging protein involved in mineral and vitamin D metabolism.
MedLine Citation:
PMID:  17332731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients undergoing dialysis with multiple accelerated age-related disorders, including hypoactivity, sterility, skin thinning, muscle atrophy, osteoporosis, vascular calcifications, soft-tissue calcifications, defective hearing, thymus atrophy, pulmonary emphysema, ataxia, and abnormalities of the pituitary gland, as well as hypoglycemia, hyperphosphatemia, and paradoxically high-plasma calcitriol levels. Conversely, mice overexpressing klotho show an extended existence and a slow aging process through a mechanism that may involve the induction of a state of insulin and oxidant stress resistance. Two molecules are produced by the klotho gene, a membrane bound form and a circulating form. However, their precise biological roles and molecular functions have been only partly deciphered. Klotho can act as a circulating factor or hormone, which binds to a not yet identified high-affinity receptor and inhibits the intracellular insulin/insulin-like growth factor-1 (IGF-1) signaling cascade; klotho can function as a novel beta-glucuronidase, which deglycosylates steroid beta-glucuronides and the calcium channel transient receptor potential vallinoid-5 (TRPV5); as a cofactor essential for the stimulation of fibroblast growth factor (FGF) receptor by FGF23. The two last functions have propelled klotho to the group of key factors regulating mineral and vitamin D metabolism, and have also stimulated the interest of the nephrology community. The purpose of this review is to provide a nephrology-oriented overview of klotho and its potential implications in normal and altered renal function states.
Authors:
P-Ureña Torres; D Prié; V Molina-Blétry; L Beck; C Silve; G Friedlander
Publication Detail:
Type:  Journal Article; Review     Date:  2007-02-28
Journal Detail:
Title:  Kidney international     Volume:  71     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-12     Completed Date:  2007-06-18     Revised Date:  2012-04-19    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-7     Citation Subset:  IM    
Affiliation:
Service de Néphrologie et Dialyse, Clinique de l'Orangerie, Aubervilliers, France. urena.pablo@wanadoo.fr
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism,  physiology*
Animals
Bone and Bones / metabolism
Glucuronidase / genetics,  metabolism,  physiology*
Humans
Kidney / metabolism*
Minerals / metabolism*
RNA, Messenger / metabolism
Vitamin D / metabolism*
Chemical
Reg. No./Substance:
0/Minerals; 0/RNA, Messenger; 1406-16-2/Vitamin D; EC 3.2.1.31/Glucuronidase; EC 3.2.1.31/klotho protein
Comments/Corrections
Comment In:
Kidney Int. 2012 Apr;81(7):611-2   [PMID:  22419041 ]

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