| Klotho: an antiaging protein involved in mineral and vitamin D metabolism. | |
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MedLine Citation:
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PMID: 17332731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients undergoing dialysis with multiple accelerated age-related disorders, including hypoactivity, sterility, skin thinning, muscle atrophy, osteoporosis, vascular calcifications, soft-tissue calcifications, defective hearing, thymus atrophy, pulmonary emphysema, ataxia, and abnormalities of the pituitary gland, as well as hypoglycemia, hyperphosphatemia, and paradoxically high-plasma calcitriol levels. Conversely, mice overexpressing klotho show an extended existence and a slow aging process through a mechanism that may involve the induction of a state of insulin and oxidant stress resistance. Two molecules are produced by the klotho gene, a membrane bound form and a circulating form. However, their precise biological roles and molecular functions have been only partly deciphered. Klotho can act as a circulating factor or hormone, which binds to a not yet identified high-affinity receptor and inhibits the intracellular insulin/insulin-like growth factor-1 (IGF-1) signaling cascade; klotho can function as a novel beta-glucuronidase, which deglycosylates steroid beta-glucuronides and the calcium channel transient receptor potential vallinoid-5 (TRPV5); as a cofactor essential for the stimulation of fibroblast growth factor (FGF) receptor by FGF23. The two last functions have propelled klotho to the group of key factors regulating mineral and vitamin D metabolism, and have also stimulated the interest of the nephrology community. The purpose of this review is to provide a nephrology-oriented overview of klotho and its potential implications in normal and altered renal function states. |
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Authors:
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P-Ureña Torres; D Prié; V Molina-Blétry; L Beck; C Silve; G Friedlander |
Publication Detail:
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Type: Journal Article; Review Date: 2007-02-28 |
Journal Detail:
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Title: Kidney international Volume: 71 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-12 Completed Date: 2007-06-18 Revised Date: 2012-04-19 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 730-7 Citation Subset: IM |
Affiliation:
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Service de Néphrologie et Dialyse, Clinique de l'Orangerie, Aubervilliers, France. urena.pablo@wanadoo.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism,
physiology* Animals Bone and Bones / metabolism Glucuronidase / genetics, metabolism, physiology* Humans Kidney / metabolism* Minerals / metabolism* RNA, Messenger / metabolism Vitamin D / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Minerals; 0/RNA, Messenger; 1406-16-2/Vitamin D; EC 3.2.1.31/Glucuronidase; EC 3.2.1.31/klotho protein |
| Comments/Corrections | |
Comment In:
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Kidney Int. 2012 Apr;81(7):611-2
[PMID:
22419041
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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