| Klinefelter's syndrome. | |
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MedLine Citation:
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PMID: 15262106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Klinefelter's syndrome is the most common genetic cause of human male infertility, but many cases remain undiagnosed because of substantial variation in clinical presentation and insufficient professional awareness of the syndrome itself. Early recognition and hormonal treatment of the disorder can substantially improve quality of life and prevent serious consequences. Testosterone replacement corrects symptoms of androgen deficiency but has no positive effect on infertility. However, nowadays patients with Klinefelter's syndrome, including the non-mosaic type, need no longer be considered irrevocably infertile, because intracytoplasmic sperm injection offers an opportunity for procreation even when there are no spermatozoa in the ejaculate. In a substantial number of azoospermic patients, spermatozoa can be extracted from testicular biopsy samples, and pregnancies and livebirths have been achieved. The frequency of sex chromosomal hyperploidy and autosomal aneuploidies is higher in spermatozoa from patients with Klinefelter's syndrome than in those from normal men. Thus, chromosomal errors might in some cases be transmitted to the offspring of men with this syndrome. The genetic implications of the fertilisation procedures, including pretransfer or prenatal genetic assessment, must be explained to patients and their partners. |
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Authors:
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Fabio Lanfranco; Axel Kamischke; Michael Zitzmann; Eberhard Nieschlag |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Lancet Volume: 364 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2004 Jul 17-23 |
Date Detail:
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Created Date: 2004-07-20 Completed Date: 2004-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 273-83 Citation Subset: AIM; IM |
Affiliation:
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Institute of Reproductive Medicine of the University of Münster, Domagkstrasse 11, D-48129 Münster, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anthropometry Humans Karyotyping Klinefelter Syndrome* / diagnosis, genetics, pathology, therapy Male Testis / pathology Testosterone / blood, therapeutic use |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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