| Klinefelter syndrome and acute basophilic leukaemia--case report. | |
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MedLine Citation:
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PMID: 20698148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia. We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells. Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias. Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules. The most characteristic cytochemical reaction is metachromatic positivity with toluidine blue. Blast are myeloperoxidase negative. Also leukemic blasts express myeloid and monocyte markers. There is no consistent chromosomal abnormality identified in this leukaemia. This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome. In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed. |
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Authors:
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Nives Ljubić; Nada Lang; Ika Kardum Skelin; Ruzica Lasan; Mara Dominis; Leila Perković; Dubraka Zupanić-Krmek; Anita Grgurević-Batinica |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Collegium antropologicum Volume: 34 ISSN: 0350-6134 ISO Abbreviation: Coll Antropol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003354 Medline TA: Coll Antropol Country: Croatia |
Other Details:
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Languages: eng Pagination: 657-60 Citation Subset: IM |
Affiliation:
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Department of Pathology and Cytology, "Sveti Duh" General Hospital, Zagreb, Croatia. niveslj@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blast Crisis Bone Marrow Cells / pathology Chromosome Aberrations Chromosome Mapping Fatal Outcome Humans Karyotyping Klinefelter Syndrome / complications*, genetics, pathology Leukemia, Basophilic, Acute / complications*, genetics, pathology Male Middle Aged Multiple Organ Failure / pathology |
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