Document Detail

Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens.
MedLine Citation:
PMID:  23141741     Owner:  NLM     Status:  Publisher    
BACKGROUND: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. OBJECTIVE: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit allergy were identified, and the diagnostic performance of specific kiwifruit allergens was investigated. METHODS: This study was part of EuroPrevall, a multicenter European study investigating several aspects of food allergy. Three hundred eleven patients with kiwifruit allergy from 12 countries representing 4 climatic regions were included. Specific IgE to 6 allergens (Act d 1, Act d 2, Act d 5, Act d 8, Act d 9, and Act d 10) and kiwifruit extract were tested by using ImmunoCAP. RESULTS: Patients from Iceland were mainly sensitized to Act d 1 (32%), those from western/central and eastern Europe were mainly sensitized to Act d 8 (pathogenesis-related class 10 protein, 58% and 44%, respectively), and those from southern Europe were mainly sensitized to Act d 9 (profilin, 31%) and Act d 10 (nonspecific lipid transfer protein, 22%). Sensitization to Act d 1 and living in Iceland were independently and significantly associated with severe kiwifruit allergy (odds ratio, 3.98 [P = .003] and 5.60 [P < .001], respectively). Using a panel of 6 kiwifruit allergens in ImmunoCAP increased the diagnostic sensitivity to 65% compared with 20% for skin prick tests and 46% ImmunoCAP using kiwi extract. CONCLUSION: Kiwifruit allergen sensitization patterns differ across Europe. The use of specific kiwifruit allergens improved the diagnostic performance compared with kiwifruit extract. Sensitization to Act d 1 and living in Iceland are strong risk factors for severe kiwifruit allergy.
Thuy-My Le; Merima Bublin; Heimo Breiteneder; Montserrat Fernández-Rivas; Riccardo Asero; Barbara Ballmer-Weber; Laura Barreales; Peter Bures; Simona Belohlavkova; Frédéric de Blay; Michael Clausen; Ruta Dubakiene; David Gislason; Els van Hoffen; Monika Jedrzejczak-Czechowicz; Marek L Kowalski; Tanya Kralimarkova; Jonas Lidholm; Asa Marknell Dewitt; Clare E N Mills; Nikolaos G Papadopoulos; Todor Popov; Ashok Purohit; Ronald van Ree; Suranjith Seneviratne; Athanasios Sinaniotis; Colin Summers; Sonia Vázquez-Cortés; Stefan Vieths; Lothar Vogel; Karin Hoffmann-Sommergruber; André C Knulst
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  -     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients ...
Next Document:  Alexithymia and low cooperativeness are associated with suicide attempts in male military personnel ...