Document Detail


Kisspeptins in human reproduction-future therapeutic potential.
MedLine Citation:
PMID:  23015158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Kisspeptins (Kps), were first found to regulate the hypothalamopituitary-gonadal axis (HPG) axis in 2003, when two groups-demonstrated that mutations of GPR54 causes idiopathic hypogonadotropic hypogonadism (IHH) characterized by delayed puberty. Objective of this review is to highlight both animal and human discoveries in KISS1/GPR54 system in last decade and extrapolate the therapeutic potential in humans from till date human studies.
DESIGN: A systematic review of international scientific literature by a search of PUBMED and the authors files was done for Kp in reproduction, metabolic control & signal transduction.
SETTING: None Patient(s): In human studies--normal subjects patients with HH, or HA.
MAIN OUTCOME MEASURES: Effects of Kp on puberty, brain sexual maturation, regulation of GnRH secretion, metabolic control of GnRH Neurons (N).
RESULTS: Kps/GPR54 are critical for brain sexual maturation, puberty and regulation of reproduction. Kps have been implicated in mediating signals to GnRH N--positive and negative feedback, metabolic input. Ability of Kp neurons to coordinate signals impinging on the HPG axis makes it one of most important regulators of reproductive axis since GnRH N's lack many receptors, with Kp neurons serving as upstream modulators.
CONCLUSIONS: Kps have proven as pivotal regulators of the reproduction, with the ability to integrate signals from both internal and external sources. Knowledge about signaling mechanisms involved in Kp stimulation of GnRH and with human studies has made it possible that therapeutically available Kp agonists/antagonists may be used for treatment of delayed puberty/HH, Hypothalamic amenorrhea and in prevention of spread of malignant ovarian/gonadal malignancies along with uses in some eating disorders.
Authors:
Kulvinder Kochar Kaur; Gautam Allahbadia; Mandeep Singh
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-09-27
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  999-1011     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology
Feedback, Physiological
Follicular Phase / physiology
Gonadotropin-Releasing Hormone / metabolism
Humans
Hypogonadism / genetics,  metabolism
Hypothalamus / metabolism
Kisspeptins / metabolism,  physiology*
Male
Mutation
Neurons / metabolism*
Puberty / physiology*
Receptors, G-Protein-Coupled / genetics,  metabolism
Sexual Maturation
Chemical
Reg. No./Substance:
0/KISS1 protein, human; 0/KISS1R protein, human; 0/Kisspeptins; 0/Receptors, G-Protein-Coupled; 33515-09-2/Gonadotropin-Releasing Hormone
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