Document Detail


Kisspeptin and the regulation of the hypothalamic-pituitary-gonadal axis in the rhesus monkey (Macaca mulatta).
MedLine Citation:
PMID:  18662732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present article reviews recent studies of monkeys and, in some cases, humans that have been conducted to examine the role of kisspeptin-GPR54 signaling in the regulation of the hypothalamic-pituitary-gonadal axis in higher primates. This area of peptide biology was initiated in 2003 by the discovery that loss of function mutations of GPR54 in man were associated with hypogonadotropic hypogonadism and absent or delayed puberty. Puberty in the monkey, an experimental model commonly used to study this fundamental developmental stage, is first described. This is followed by a review of the role of kisspeptin in the regulation of the postnatal ontogeny of GnRH pulsatility. The roles of kisspeptin in GnRH pulse generation and in the feedback loops governing gonadotropin secretion in primates are then discussed. A brief section on kisspeptin-GPR54 signaling at the pituitary and gonadal levels is also included. The review concludes with a discussion of the phenomenon of GPR54 downregulation by continuous exposure to kisspeptin and its therapeutic implications.
Authors:
Tony M Plant; Suresh Ramaswamy
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-07-10
Journal Detail:
Title:  Peptides     Volume:  30     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-30     Completed Date:  2009-03-30     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-75     Citation Subset:  IM    
Affiliation:
University of Pittsburgh School of Medicine, Department of Cell Biology and Physiology, Magee-Womens Research Institute, 204 Craft Avenue, Room B311, Pittsburgh, PA 15213, USA. plant1@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Gonadotropin-Releasing Hormone / metabolism
Gonads / physiology*
Humans
Hypothalamo-Hypophyseal System / physiology*
Luteinizing Hormone / metabolism
Macaca mulatta / anatomy & histology,  physiology*
Neurons / metabolism
Periodicity
Puberty / physiology
Receptors, G-Protein-Coupled / metabolism
Signal Transduction / physiology
Tumor Suppressor Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
HD08610/HD/NICHD NIH HHS; HD13254/HD/NICHD NIH HHS; R01 HD013254-21/HD/NICHD NIH HHS; R01 HD013254-22/HD/NICHD NIH HHS; R01 HD013254-23/HD/NICHD NIH HHS; U54 HD008610-31A1/HD/NICHD NIH HHS; U54 HD008610-31A17940/HD/NICHD NIH HHS; U54 HD008610-32/HD/NICHD NIH HHS; U54 HD008610-33/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/KISS1R protein, human; 0/Receptors, G-Protein-Coupled; 0/Tumor Suppressor Proteins; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-67-9/Luteinizing Hormone
Comments/Corrections

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