Document Detail


Kir1.1 expression in embryonic kidney epithelia.
MedLine Citation:
PMID:  14651999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
K(+) channels may regulate cell cycling, cell volume, and cell proliferation. We have recently shown a role for an inwardly rectifying K(+) channel, Kir6.1/SUR2(B), in the regulation of cell proliferation during early kidney development. Here, we show that the protein of a further K(+) channel, Kir1.1 (ROMK), is also developmentally expressed in prenatal rat kidney epithelia. In the embryonic stage, Kir1.1 protein was localized to the plasma membrane of ureteric buds and collecting ducts, and of nephron stages up to the comma-shaped body. Experimental increase in cAMP upregulated Kir1.1b (ROMK2) mRNA abundance in ureteric buds. Kir1.1 protein was restricted to the distal nephron during later postnatal development and adulthood, as has been reported. In conclusion, we demonstrate redundancy of Kir channel expression in early embryonic kidney which could suggest that Kir1.1 acts in a similar way as Kir6.1/SUR2(B) to promote cell proliferation or other developmental functions.
Authors:
Gerald S Braun; Michael F Horster; Stephan M Huber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  312     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1191-5     Citation Subset:  IM    
Affiliation:
Physiologisches Institut, Ludwig-Maximilians-Universität, 80336, Munich, Germany. gerald.braun@urz.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Cyclic AMP / metabolism*
Epithelium / embryology*,  metabolism*,  ultrastructure
Kidney / cytology,  embryology*,  metabolism*
Kidney Tubules, Collecting / cytology,  embryology,  metabolism
Nephrons / cytology,  embryology,  metabolism
Potassium Channels / metabolism*
Potassium Channels, Inwardly Rectifying*
Signal Transduction / physiology*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Kcnj1 protein, rat; 0/Potassium Channels; 0/Potassium Channels, Inwardly Rectifying; 60-92-4/Cyclic AMP

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