| Kinoid of human tumor necrosis factor-alpha for rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 21385114 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Anti-TNF-α drugs have dramatically changed treatment of rheumatoid arthritis (RA) in terms of both clinical control and articular damage prevention. Despite this, they hold some important drawbacks, such as frequent therapeutic failures and high costs. Anti-TNF-α active immunization, with a therapeutic vaccine against TNF-α, is a promising alternative anti-TNF-α targeting strategy, potentially devoid of treatment limitations of some of current anti-TNF blocking agents. Areas covered: This review covers the preclinical proof-of-concept of anti-TNF-α vaccination with the kinoid of human TNF-α (TNFK) and analyzes the body of evidence forming the rationale for the application of this strategy in RA and other TNF-α-dependent diseases. We describe the theoretical bases of anti-TNF-α active immunization and of experimental data supporting the applicability of TNFK to human disease in terms of both safety and efficacy. Expert opinion: Based on preclinical efficacy and safety data supporting its feasibility in a Phase I - II trial in Crohn's disease, anti-TNF-α vaccination with TNFK has entered the phase of clinical development and promises to be a valuable anti-TNF-α targeting strategy in human disease. The focus is made in the first clinical trial in RA (Phase II) on the efficacy in active RA patients having developed antibodies against anti-TNF mAbs. |
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Authors:
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Luca Semerano; Eric Assier; Laure Delavallée; Marie-Christophe Boissier |
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Publication Detail:
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Type: Journal Article Date: 2011-03-09 |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: 11 ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: England |
Other Details:
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Languages: eng Pagination: 545-50 Citation Subset: IM |
Affiliation:
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Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Avicenne, Rheumatology Department, 125 rue de Stalingrad, 93000 Bobigny, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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