Document Detail


Kinetochore structure and function.
MedLine Citation:
PMID:  16214339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation. Kinetochores are assembled on centromeric chromatin through complex pathways that are coordinated with the cell cycle. In the light of recent discoveries on how proteins assemble onto kinetochores and interact with each other, we review these findings in this article (which is part of the Chromosome Segregation and Aneuploidy series), and discuss their implications for the current mitotic checkpoint models - the template model and the two-step model. The template model proposes that Mad1-Mad2 at kinetochores acts as a template to change the conformation of another binding molecule of Mad2. This templated change in conformation is postulated as a mechanism for the amplification of the 'anaphase wait' signal. The two-step model proposes that the mitotic checkpoint complex (MCC) is the kinetochore-independent anaphase inhibitor, and the role of the unaligned kinetochore is to sensitize the anaphase-promoting complex/cyclosome (APC/C) to MCC-mediated inhibition.
Authors:
Gordon K Chan; Song-Tao Liu; Tim J Yen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2005-10-07
Journal Detail:
Title:  Trends in cell biology     Volume:  15     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  589-98     Citation Subset:  IM    
Affiliation:
Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2. gordonch@cancerboard.ab.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle Proteins / physiology
Chromosome Segregation / physiology
Humans
Kinetochores / metabolism,  physiology*
Microtubule-Associated Proteins / physiology
Microtubules / metabolism
Models, Biological
Protein Binding
Ubiquitin-Protein Ligase Complexes / physiology
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Microtubule-Associated Proteins; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex

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