Document Detail


Kinetics of sodium homeostasis in rats: rapid excretion and equilibration rates.
MedLine Citation:
PMID:  3381905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In normal humans, when sodium intake is abruptly reduced from a high to a very low level, renal sodium excretion falls exponentially (half time approximately 24 h), and several days are required to achieve external sodium balance, where intake equals excretion. Because much of our knowledge of intrarenal mechanisms comes from the rat, we studied their capacity to handle sodium. In two strains of rat, Sprague-Dawley (SD) and Wistar-Kyoto (WKY), whether the sodium load was administered intravenously, by gavage, or by spontaneous feeding, the slope relating sodium excretion to time was 8-10 times more rapid than in humans, reflecting half times of 2-3 h, and external sodium balance was achieved in hours rather than days. The combination of normal rat nocturnal feeding patterns and the rapidity of the response result in a daily spontaneous transition from an expanded state with a high or intermediate level of sodium excretion to a more contracted state, with minimal sodium excretion. Studies designed to assess sodium homeostasis in rats, and related renal and hormonal changes, must consider these rapid transitions, which are related, perhaps, to the rats' persistent and remarkably rapid growth.
Authors:
E J Holtzman; L M Braley; G H Williams; N K Hollenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-15     Completed Date:  1988-07-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1001-6     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Circadian Rhythm
Female
Homeostasis*
Kinetics
Male
Rats
Rats, Inbred Strains
Rats, Inbred WKY
Sodium / metabolism*
Sodium, Dietary / metabolism
Species Specificity
Chemical
Reg. No./Substance:
0/Sodium, Dietary; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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