Document Detail

Kinetics of serum brain-derived neurotrophic factor following low-intensity versus high-intensity exercise in men and women.
MedLine Citation:
PMID:  22964969     Owner:  NLM     Status:  In-Data-Review    
Physical activity has been shown to enhance circulating brain-derived neurotrophic factor (BDNF) in animals and humans. However, the exact time course and sex-specific modulation of peripheral BDNF in response to exercise are still poorly understood. We examined the kinetics of BDNF serum concentrations in response to perceived high-intensity and low-intensity exercise, and during a subsequent recovery period by taking several blood samples during each phase. Furthermore, we compared the BDNF concentration between young men and women taking oral contraceptives. We found transient BDNF elevations during physical activity only for the high-intensity condition. Here, BDNF reached its maximum serum concentration after 20 min of exercise, and returned to baseline after approximately 10 min of recovery. Although there were no sex differences during baselineor recovery, the increase in the BDNF concentration during the exercise phase was more pronounced in men than in women.
Maren Schmidt-Kassow; Sarah Schädle; Sascha Otterbein; Christian Thiel; Alexandra Doehring; Jörn Lötsch; Jochen Kaiser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  23     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  889-93     Citation Subset:  IM    
aInstitute of Medical Psychology bPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology cInstitute of Sports Sciences, Department of Sports Medicine, Goethe University, Frankfurt am Main, Germany.
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