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Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection.
MedLine Citation:
PMID:  22429018     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Trypanosoma evansi (T. evansi) causes a wasting disease in almost all mammals. T. evansi infection gives rise to the inflammatory responses which contribute to the development of inflammation-associated tissue injury. To determine what kinds of inflammatory molecules play roles in the pathogenicity of T. evansi infection, polymerase chain reaction (PCR) array analysis was performed on samples from the infected and uninfected mice. The inflammatory cytokine and chemokine storm, caused mainly by macrophages, was observed. On the other hand, the expression levels of Ccl8 and Il10 in splenocytes were also markedly increased. These results suggested an augmentation in the number and activity of regulatory dendritic cells (DCs). Therefore, the kinetics of regulatory DCs in T. evansi-infected mice were investigated. During T. evansi infection, the regulatory DCs became prevalent, with reducing the amount of inflammatory DCs. Interestingly, when the regulatory DCs were implanted into T. evansi-infected mice, the survival was prolonged and the expression levels of inflammatory molecules were suppressed. Taken together, these results showed that a subset of regulatory DCs acted as a potential regulator of the inflammatory responses. © 2012 Blackwell Publishing Ltd.
Authors:
Hirohisa Mekata; Satoru Konnai; Claro N Mingala; Nancy S Abes; Charito A Gutierrez; Alan P Dargantes; William H Witola; Noboru Inoue; Misao Onuma; Shiro Murata; Kazuhiko Ohashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-16
Journal Detail:
Title:  Parasite immunology     Volume:  -     ISSN:  1365-3024     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan Animal Health Laboratory, Philippine Carabao Center, Science City of Munoz, Nueva Ecija 3120, Philippines College of Veterinary Medicine, Central Mindanao University, Musuan 8710, Bukidnon, Philippines Department of Agricultural and Environmental Sciences, Tuskegee University, Tuskegee, AL 36088, USA National Research Centre for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.
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