Document Detail

Kinetics of procalcitonin in cardiogenic shock and in septic shock. Preliminary data.
MedLine Citation:
PMID:  20698733     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In cardiac acute patients, data on procalcitonin (PCT) are controversial and the clinical interpretation of absolute PCT values represents a major challenge since they may be influenced by several factors. No data are so far available on the dynamics of PCT levels in patients with cardiogenic shock. AIMS: to evaluate the serum evolution of PCT during intensive cardiac care unit (ICCU) staying in a group of 24 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous intervention (PCI) with no laboratory or clinical sign of infection. Furthermore we assessed the kinetics of PCT in a series of 24 patients with septic shock. RESULTS: In septic shock, no significant difference was detectable in PCT kinetics between survivors (R2 = 0.90; P = 0.051) and non-survivors (R2 = 0.63; P = 0.204). In cardiogenic shock, survivors exhibited a significant reduction in PCT values (R2 = 0.94; P = 0.032) while non survivors did not (R2 = 0.68; P = 0.178). CONCLUSIONS: differently from septic shock, cardiogenic shock following STEMI was associated with heterogeneous patterns of temporal PCT variations since only patients who survived exhibited a significant PCT reduction during ICCU stay. Our findings support the contention that the 'dynamic' approach may be more reliable that the static one especially in cardiogenic shock.
Claudio Picariello; Chiara Lazzeri; Serafina Valente; Marco Chiostri; Paola Attanà; Gian Franco Gensini
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acute cardiac care     Volume:  12     ISSN:  1748-295X     ISO Abbreviation:  Acute Card Care     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  96-101     Citation Subset:  IM    
Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
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MeSH Terms
Aged, 80 and over
Biological Markers
C-Reactive Protein / metabolism
Calcitonin / blood*
Electrocardiogram Pattern
Intensive Care Units
Middle Aged
Myocardial Infarction / blood*,  complications,  mortality,  therapy
Protein Precursors / blood*
Shock, Cardiogenic / blood*,  diagnosis*,  etiology
Shock, Septic / blood*,  diagnosis*
Survival Analysis
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein

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