Document Detail


Kinetics of procalcitonin in cardiogenic shock and in septic shock. Preliminary data.
MedLine Citation:
PMID:  20698733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In cardiac acute patients, data on procalcitonin (PCT) are controversial and the clinical interpretation of absolute PCT values represents a major challenge since they may be influenced by several factors. No data are so far available on the dynamics of PCT levels in patients with cardiogenic shock. AIMS: to evaluate the serum evolution of PCT during intensive cardiac care unit (ICCU) staying in a group of 24 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous intervention (PCI) with no laboratory or clinical sign of infection. Furthermore we assessed the kinetics of PCT in a series of 24 patients with septic shock. RESULTS: In septic shock, no significant difference was detectable in PCT kinetics between survivors (R2 = 0.90; P = 0.051) and non-survivors (R2 = 0.63; P = 0.204). In cardiogenic shock, survivors exhibited a significant reduction in PCT values (R2 = 0.94; P = 0.032) while non survivors did not (R2 = 0.68; P = 0.178). CONCLUSIONS: differently from septic shock, cardiogenic shock following STEMI was associated with heterogeneous patterns of temporal PCT variations since only patients who survived exhibited a significant PCT reduction during ICCU stay. Our findings support the contention that the 'dynamic' approach may be more reliable that the static one especially in cardiogenic shock.
Authors:
Claudio Picariello; Chiara Lazzeri; Serafina Valente; Marco Chiostri; Paola Attanà; Gian Franco Gensini
Related Documents :
10660963 - Primary coronary angioplasty in acute myocardial infarction excluded from thrombolysis:...
19077633 - Esophageal echo-doppler monitoring in burn shock resuscitation: are hemodynamic variabl...
12662213 - Effects of direct mechanical ventricular assistance on regional myocardial function in ...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acute cardiac care     Volume:  12     ISSN:  1748-295X     ISO Abbreviation:  Acute Card Care     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  96-101     Citation Subset:  IM    
Affiliation:
Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. claudx@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Markers
C-Reactive Protein / metabolism
Calcitonin / blood*
Electrocardiogram Pattern
Female
Humans
Intensive Care Units
Male
Middle Aged
Myocardial Infarction / blood*,  complications,  mortality,  therapy
Protein Precursors / blood*
Shock, Cardiogenic / blood*,  diagnosis*,  etiology
Shock, Septic / blood*,  diagnosis*
Survival Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevention and treatment of no-reflow.
Next Document:  The relationship between hypertension and salt intake in Turkish population: SALTURK study.