Document Detail

Kinetics of a phase transition in a frozen solution.
MedLine Citation:
PMID:  1592189     Owner:  NLM     Status:  MEDLINE    
The increased use of lyophilization in the preservation of biologicals, foods, and pharmaceuticals has revealed problems of discoloration, meltback, puffing, and collapse, which can result in unacceptable products. Literature reports suggest that some of these problems are related to phase transitions occurring in the frozen solutions. This paper describes the crystallization of mannitol and cefazolin sodium in frozen solution. Data were collected using calorimetric methods in both an isothermal and non-isothermal mode. Analysis of cefazolin sodium data, using the Johnson-Mehl-Avrami equation, indicated that there was a mechanism of heterogeneous nucleation of a two dimensional growth habit. Mannitol data indicated that the controlling crystallization mechanism was not constant over the temperature range studied.
L A Gatlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developments in biological standardization     Volume:  74     ISSN:  0301-5149     ISO Abbreviation:  Dev. Biol. Stand.     Publication Date:  1992  
Date Detail:
Created Date:  1992-07-02     Completed Date:  1992-07-02     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0427140     Medline TA:  Dev Biol Stand     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  93-103; discussion 104     Citation Subset:  IM    
Glaxo Inc., Research Triangle Park, NC 27709.
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MeSH Terms
Calorimetry, Differential Scanning
Freeze Drying*
Reg. No./Substance:
0/Solutions; 25953-19-9/Cefazolin; 69-65-8/Mannitol

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