Document Detail


Kinetics of phagocytosis in the normal canine iridocorneal angle.
MedLine Citation:
PMID:  6524729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microspheres of 3 different sizes were infused separately into the eyes of dogs with normotensive and hypertensive intraocular pressures. Latex spheres (0.5 or 1.0 micron) or 3.0 micron plastic spheres were added to Ringer's solution with 6% gelatin. Initially, this mixture was injected into the anterior chamber of dogs with intraocular pressures of 20, 50, or 75 mm of Hg. After 10, 20, 30, 60, or 90 minutes had elapsed, the dogs were euthanatized and the gelatin was hardened. Tissues were subsequently studied by light and transmission electron microscopies. Phagocytosis of the 0.5 and 1.0 micron spheres by trabecular cells was first detected within 10 minutes and within 20 minutes for the 3.0 microns spheres. Migration of cells in the corneoscleral trabecular meshwork was observed after 30 minutes. Phagocytosis was less active at hypertensive pressures and had larger sphere sizes. Microspheres in the uveal trabecular meshwork were ingested mostly by macrophages and polymorphonuclear leukocytes.
Authors:
D A Samuelson; K N Gelatt; G G Gum
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of veterinary research     Volume:  45     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-02-26     Completed Date:  1985-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2359-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cornea / ultrastructure
Dogs / physiology*
Eye / ultrastructure*
Intraocular Pressure
Iris / ultrastructure
Macrophages / physiology
Microscopy, Electron
Microspheres
Neutrophils / physiology
Ocular Physiological Phenomena
Phagocytosis*
Sclera / ultrastructure
Time Factors
Uvea / ultrastructure
Grant Support
ID/Acronym/Agency:
R01 EY0193205/EY/NEI NIH HHS; T32EY07060/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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