Document Detail


Kinetics of peritoneal drug transport in rats: an application of the pore theory of transcapillary exchange.
MedLine Citation:
PMID:  3171925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to quantitatively describe the peritoneal transport of drugs, this paper proposes a kinetic model that is based on the hydrodynamic pore theory of transcapillary exchange, and incorporates an explicit description of volume and osmolality changes in the dialysate. Sulfisoxazole (SIX) and benzoic acid (BA) were used as model compounds. Following intraperitoneal administration of dialysate in rats, the osmolality, volume, and drug concentration in the dialysate were measured with respect to time. The obtained data were analyzed to give hydrodynamic parameters for solvent and a solute (including drug) by a computer-aided curve-fitting procedure according to the differential equations derived from the model. The present method, requiring no approximation of the changes in dialysate volume, made it possible to predict the concentration profiles of BA under different initial conditions of dialysate (i.e., different osmolality and volume). Solvent drag effect contributed little to the peritoneal transport of SIX and slightly to that of BA. It was also found that the peritoneal transport of BA is blood-flow limited while that of SIX is diffusion limited.
Authors:
E Nakashima; F Ishikawa; H Sato; Y Deguchi; I Tamai; R Matsushita; F Ichimura; A Tsuji
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  77     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-11-07     Completed Date:  1988-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  481-8     Citation Subset:  IM    
Affiliation:
Hospital Pharmacy, Kanazawa University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active
Blood Proteins / metabolism
Capillaries / metabolism*
Male
Models, Biological
Osmolar Concentration
Peritoneal Dialysis*
Pharmaceutical Preparations / blood,  metabolism*
Protein Binding
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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