Document Detail


Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics.
MedLine Citation:
PMID:  18356477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with chronic obstructive pulmonary disease (COPD) have slowed pulmonary O(2) uptake (Vo(2)(p)) kinetics during exercise, which may stem from inadequate muscle O(2) delivery. However, it is currently unknown how COPD impacts the dynamic relationship between systemic and microvascular O(2) delivery to uptake during exercise. We tested the hypothesis that, along with slowed Vo(2)(p) kinetics, COPD patients have faster dynamics of muscle deoxygenation, but slower kinetics of cardiac output (Qt) following the onset of heavy-intensity exercise. We measured Vo(2)(p), Qt (impedance cardiography), and muscle deoxygenation (near-infrared spectroscopy) during heavy-intensity exercise performed to the limit of tolerance by 10 patients with moderate-to-severe COPD and 11 age-matched sedentary controls. Variables were analyzed by standard nonlinear regression equations. Time to exercise intolerance was significantly (P < 0.05) lower in patients and related to the kinetics of Vo(2)(p) (r = -0.70; P < 0.05). Compared with controls, COPD patients displayed slower kinetics of Vo(2)(p) (42 +/- 13 vs. 73 +/- 24 s) and Qt (67 +/- 11 vs. 96 +/- 32 s), and faster overall kinetics of muscle deoxy-Hb (19.9 +/- 2.4 vs. 16.5 +/- 3.4 s). Consequently, the time constant ratio of O(2) uptake to mean response time of deoxy-Hb concentration was significantly greater in patients, suggesting a slower kinetics of microvascular O(2) delivery. In conclusion, our data show that patients with moderate-to-severe COPD have impaired central and peripheral cardiovascular adjustments following the onset of heavy-intensity exercise. These cardiocirculatory disturbances negatively impact the dynamic matching of O(2) delivery and utilization and may contribute to the slower Vo(2)(p) kinetics compared with age-matched controls.
Authors:
Gaspar R Chiappa; Audrey Borghi-Silva; Leonardo F Ferreira; Claúdia Carrascosa; Cristino Carneiro Oliveira; Joyce Maia; Ana Cristina Gimenes; Fernando Queiroga; Danilo Berton; Eloara M V Ferreira; Luis Eduardo Nery; J Alberto Neder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-06-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1341-50     Citation Subset:  IM    
Affiliation:
Pulmonary Function and Clinical Exercise Physiology Unit, Division of Respiratory Diseases, Department of Medicine, Federal University of São Paulo-Paulista School of Medicine, Rua Professor Francisco de Castro 54, Vila Clementino, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aged
Algorithms
Anaerobic Threshold / physiology
Blood Pressure / physiology*
Electrocardiography
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology
Female
Humans
Kinetics
Male
Middle Aged
Muscle, Skeletal / metabolism*,  physiology*,  physiopathology
Oxygen Consumption / physiology*
Pulmonary Disease, Chronic Obstructive / metabolism*,  physiopathology*
Pulmonary Gas Exchange / physiology
Respiratory Function Tests
Spectroscopy, Near-Infrared
Spirometry
Stroke Volume / physiology*

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