Document Detail


Kinetics and mechanism of the hydrolysis of a 2-substituted imidazoline, cibenzoline (cifenline).
MedLine Citation:
PMID:  3598889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of a kinetic and mechanistic study of the hydrolysis of a new antiarrhythmic agent, cibenzoline, are reported. The reaction is subject to specific base catalysis which proceeds via the protonated cibenzolinium ion. No evidence for the existence of a "pseudobase"-type intermediate could be found. The results support only one of two different mechanisms which have been proposed previously for the hydrolysis of this class of compounds.
Authors:
A J Ross; M V Go; D L Casey; D J Palling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  76     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-28     Completed Date:  1987-07-28     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Hydrogen-Ion Concentration
Hydrolysis
Imidazoles / metabolism*
Kinetics
Magnetic Resonance Spectroscopy
Potentiometry
Spectrophotometry, Ultraviolet
Temperature
Chemical
Reg. No./Substance:
0/Imidazoles; 53267-01-9/cifenline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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