| Kinetics of lactate metabolism after submaximal ergometric exercise in HIV-infected patients. | |
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MedLine Citation:
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PMID: 15369513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: It is unknown whether high levels of lactate result from enhanced production or decreased degradation. We therefore investigated differences in the kinetics of plasma lactic acid in HIV-infected patients receiving or not receiving highly active antiretroviral therapy (HAART) and in uninfected controls after submaximal ergometric exercise. METHODS: Ten healthy controls, 11 HIV-infected therapy-naïve patients, 15 HIV-infected patients on HAART with normal baseline lactate levels, and nine HIV-infected patients on HAART with elevated baseline lactate levels >2 mmol/L performed 10 min of ergometric exercise, with a heart rate of 200 beats/min minus age. Lactate levels were measured at baseline, at the end of exercise and 15, 30, 45, 60 and 120 min thereafter. RESULTS: Mean baseline lactate levels were 1.4, 1.5, 1.5 and 2.8 mmol/L in the controls, the therapy-naïve patients, the patients on HAART with normal lactate levels and the patients on HAART with elevated lactate levels, respectively. Maximum lactate levels after exercise were similar in all groups (9.7, 9.4, 9.0 and 10.1 mmol/L, respectively). Significant differences were found in the slope of lactate decline between controls and untreated individuals (P=0.038) and between patients on HAART with normal baseline lactate and patients on HAART with elevated baseline lactate (P=0.028). CONCLUSIONS: Differences in lactate metabolism do exist between healthy controls and HIV-infected therapy-naïve individuals. Thus, HIV infection in itself may influence lactate levels. Elevated baseline lactate levels are associated with a delayed decline of lactate after exercise. These results could be explained by impaired lactate clearance. Lactate production upon exercise does not seem to be affected by baseline lactate levels. |
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Authors:
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A-M Bauer; T Sternfeld; S Horster; M Schunk; F-D Goebel; J R Bogner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: HIV medicine Volume: 5 ISSN: 1464-2662 ISO Abbreviation: HIV Med. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-16 Completed Date: 2004-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100897392 Medline TA: HIV Med Country: England |
Other Details:
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Languages: eng Pagination: 371-6 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases, Medizinische Poliklinik, University Hospital of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiretroviral Therapy, Highly Active Case-Control Studies Ergometry Exercise* Female HIV Infections / drug therapy, metabolism*, physiopathology Humans Lactic Acid / metabolism* Male Middle Aged Reverse Transcriptase Inhibitors / therapeutic use Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Reverse Transcriptase Inhibitors; 50-21-5/Lactic Acid |
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