Document Detail

Kinetics of intraocular gases. Disappearance of air, sulfur hexafluoride, and perfluoropropane after pars plana vitrectomy.
MedLine Citation:
PMID:  2719578     Owner:  NLM     Status:  MEDLINE    
Intraocular gas bubbles are an important source of internal tamponade for the treatment of retinal breaks in eyes requiring vitrectomy. The kinetics of disappearance of air, 20% sulfur hexafluoride, and 10% perfluoropropane were prospectively evaluated in 76 eyes undergoing pars plana vitrectomy. The absorption of each gas approximated a first-order kinetic equation with respect to bubble volume. The half-life of air was 1.6 days in phakic and 0.9 days in aphakic eyes. The half-life of 20% sulfur hexafluoride was 2.8 days in phakic and 2.4 days in aphakic eyes. The half-life of 10% perfluoropropane was 5.7 days in phakic, 4.5 days in aphakic, and 4.3 days in pseudophakic eyes. The difference in half-life among the three gases was significant. Intraocular gases had a shorter half-life in aphakic than in phakic eyes.
J T Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  107     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2008-05-30    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  687-91     Citation Subset:  AIM; IM    
Department of Ophthalmology and Visual Science, Yale University, New Haven, Conn. 06510-8061.
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MeSH Terms
Fluorides / pharmacokinetics*
Fluorocarbons / pharmacokinetics*
Gases / administration & dosage*,  pharmacokinetics
Postoperative Period
Regression Analysis
Sulfur Hexafluoride / pharmacokinetics*
Vitrectomy / methods*
Reg. No./Substance:
0/Fluorides; 0/Fluorocarbons; 0/Gases; 2551-62-4/Sulfur Hexafluoride; 76-19-7/perflutren

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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