Document Detail


Kinetics of insulin clearance by the liver in perfused liver-pancreas.
MedLine Citation:
PMID:  7009144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between hepatic insulin extraction velocity and portal plasma insulin concentration was assessed using in situ perfused liver-pancreas preparations from rats fasted 24 or 48 hours. During hepatic transit of the first phase of glucose-stimulated insulin secretion, hepatic extraction velocities followed first order kinetics for all insulin concentrations observed (less than 1 to 17 ng/ml). During the second phase of insulin release, saturation of the insulin removal process occurred at insulin concentrations between 12 and 14 ng/ml. At non-saturating insulin levels, livers from rats fasted 24 hours clear insulin at about 4.0 ml/min corresponding to an extraction ratio of 52%. In contrast, livers of liver-pancreases from 48 hour fasted rats clear insulin at 2.4 ml/min with an extraction ratio of 31%.
Authors:
J S Striffler; D L Curry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrine research communications     Volume:  7     ISSN:  0093-6391     ISO Abbreviation:  Endocr Res Commun     Publication Date:  1980  
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426337     Medline TA:  Endocr Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Fasting
Insulin / blood,  metabolism*
Liver / metabolism*
Male
Metabolic Clearance Rate
Pancreas / metabolism*
Perfusion
Rats
Grant Support
ID/Acronym/Agency:
AM-04732/AM/NIADDK NIH HHS; AM-11854/AM/NIADDK NIH HHS; AM-17688/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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