Document Detail

Kinetics and haematological effects of erythropoietin in horses.
MedLine Citation:
PMID:  7889038     Owner:  NLM     Status:  MEDLINE    
A plasma kinetic study of erythropoietin (EPO) was carried out in 4 horses after subcutaneous administration (30 IU/kg bwt) of recombinant human erythropoietin (rhEPO). At standardized intervals for 48 h before injection and for 60 h post-administration, the EPO plasma levels were determined with an immunoradiometric assay based on a sandwich technique. The peak plasma concentration (30-113 mIU/ml) was observed after a delay ranging from 6 to 9 h post-administration and the drug levels reached a physiological value around 60 h following rhEPO injection. Moreover, reference values for plasma EPO concentrations, which were separately determined in 70 racehorses and 34 sport equines, ranged between 0 and 9 mlU/ml. After drug administration, no significant variations in red blood cell count, haemoglobin concentration, haematocrit or mean red blood cell volume were observed in the 4 animals. Further, minimal variations in these parameters were detected in a horse which received three 120 IU rhEPO/kg bwt doses successively. Therefore, high rhEPO doses are probably required to induce a visible haematological effect in equine species.
P Jaussaud; M Audran; R L Gareau; A Souillard; I Chavanet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary research     Volume:  25     ISSN:  0928-4249     ISO Abbreviation:  Vet. Res.     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9309551     Medline TA:  Vet Res     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  568-73     Citation Subset:  IM    
INRA-ENVL, Laboratoire de Toxicologie Métabolique, Ecole Vétérinaire de Lyon, Marcy-l'Etoile, France.
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MeSH Terms
Erythrocyte Count / drug effects,  veterinary
Erythropoietin / blood,  pharmacokinetics,  pharmacology*,  secretion
Horses / blood*
Recombinant Proteins / pharmacokinetics,  pharmacology
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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