| Kinetics of gadobenate dimeglumine in isolated perfused rat liver: MR imaging evaluation. | |
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MedLine Citation:
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PMID: 12944603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare in the entire liver, the hepatic kinetics of gadobenate dimeglumine (Gd-BOPTA) and gadopentetate dimeglumine (Gd-DTPA) and to evaluate the hepatic transport of Gd-BOPTA. MATERIALS AND METHODS: The authors studied both contrast agents in isolated perfused rat livers by measuring the magnetic resonance (MR) signal intensity (SI) in 12 rats, as well as the gadolinium concentrations in hepatic tissues in 42 rats. The intrahepatic transport of Gd-BOPTA was investigated with pharmacologic antagonism by using bromosulfophthalein. MR imaging was performed at 1.5 T with a fast gradient-echo T1-weighted MR sequence. RESULTS: The hepatic kinetics based on the MR SI measured over time showed a rapid steady state during Gd-DTPA perfusion, while the SI continuously increased during the 30-minute Gd-BOPTA perfusion period. The pharmacokinetic modeling indicated that the half-lives of Gd-DTPA entry and exit were identical (mean, 1.3 minutes +/- 0.9 [standard error of mean]) and shorter than those observed with Gd-BOPTA (P <.001). The uptake of Gd-BOPTA was faster (mean half-life, 4.8 minutes +/- 0.3) than the washout (mean half-life, 17.5 minutes +/- 2.8) (P =.001). The combined perfusion of bromosulfophthalein and Gd-BOPTA decreased the SI enhancement in comparison with the perfusion of Gd-BOPTA alone (mean, 0.56 +/- 0.03 vs 2.54 +/- 0.39, P <.001). The entry and exit kinetic parameters obtained during the perfusion of Gd-BOPTA plus bromosulfophthalein were identical and comparable to those obtained during Gd-DTPA perfusion (P =.95). Acute bile duct ligation did not interfere with the uptake of Gd-BOPTA in hepatocytes, but it slowed down the excretion by approximately 50%. Measurements of gadolinium concentrations in hepatic tissues confirmed these findings. CONCLUSION: In the liver, the hepatospecific contrast agent Gd-BOPTA enters into hepatocytes likely through the organic anion transporting peptide 1. |
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Authors:
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Catherine M Pastor; Corinne Planchamp; Sibylle Pochon; Vito Lorusso; Xavier Montet; Joachim Mayer; Francois Terrier; Jean-Paul Vallee |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2003-08-27 |
Journal Detail:
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Title: Radiology Volume: 229 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-01 Completed Date: 2003-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 119-25 Citation Subset: AIM; IM |
Copyright Information:
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Copyright RSNA, 2003 |
Affiliation:
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Department of Radiology, Hôpital Universitaire de Genève, Rue Micheli-du-Crest 24, Bâtiment C, Room 6-795, 1211 Geneva 14, Switzerland. catherine.pastor@hcuge.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Contrast Media / pharmacokinetics*, pharmacology Gadolinium / diagnostic use, pharmacokinetics*, pharmacology Gadolinium DTPA / diagnostic use, pharmacokinetics, pharmacology Liver / anatomy & histology, metabolism* Magnetic Resonance Imaging* Male Meglumine / analogs & derivatives*, diagnostic use, pharmacokinetics*, pharmacology Organometallic Compounds / diagnostic use, pharmacokinetics*, pharmacology Oxygen Consumption / drug effects Portal Pressure / drug effects Rats Rats, Sprague-Dawley Sulfobromophthalein / pharmacokinetics, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 297-83-6/Sulfobromophthalein; 6284-40-8/Meglumine; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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