| Kinetics of enzyme inhibition by active molluscicidal agents ferulic acid, umbelliferone, eugenol and limonene in the nervous tissue of snail Lymnaea acuminata. | |
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MedLine Citation:
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PMID: 18814203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ferulic acid, umbelliferone (Ferula asafoetida), eugenol (Syzygium aromaticum) and limonene (Carum carvi) are active molluscicidal components that inhibited the activity of alkaline phosphatase and acetylcholinesterase in in vivo and in vitro exposure of Lymnaea acuminata. It was observed that ferulic acid, umbelliferone and eugenol are competitive and limonene is a competitive-non-competitive inhibitor of alkaline phosphatase. Ferulic acid and umbelliferone are competitive, whereas eugenol and limonene are competitive-non-competitive and uncompetitive inhibitors of acetylcholinesterase, respectively. |
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Authors:
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Pradeep Kumar; V K Singh; D K Singh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 172-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, UP India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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metabolism Alkaline Phosphatase / antagonists & inhibitors Animals Coumaric Acids / pharmacology Cyclohexenes / pharmacology Enzyme Inhibitors / pharmacology* Eugenol / pharmacology Kinetics Lymnaea / drug effects, enzymology* Molluscacides / pharmacology* Nerve Tissue / drug effects, enzymology* Terpenes / pharmacology Umbelliferones / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Coumaric Acids; 0/Cyclohexenes; 0/Enzyme Inhibitors; 0/Molluscacides; 0/Terpenes; 0/Umbelliferones; 1135-24-6/ferulic acid; 138-86-3/limonene; 93-35-6/7-hydroxycoumarin; 97-53-0/Eugenol; EC 3.1.1.7/Acetylcholinesterase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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