Document Detail


Kinetics of elimination of mesitylene and 3,5-dimethylbenzoic acid after experimental human exposure.
MedLine Citation:
PMID:  7618149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possibility of evaluating occupational exposure to mesitylene based on the determination of unchanged solvent in capillary blood or 3,5-dimethylbenzoic acid in urine was investigated. The volunteers were exposed to mesitylene in a toxicological chamber (range 10-150 mg/m3). Concentrations of solvent or its metabolite in biological material were determined by gas chromatography. The toxicokinetic data concerning retention in the lung, absorption and elimination of mesitylene and its metabolite in biological fluids were obtained. The highest correlation coefficient value was obtained for the relationship between the absorbed dose of mesitylene and the excretion rate of 3,5-dimethylbenzoic acid in urine (r = 0.95). The biological indices of exposure for mesitylene have been proposed, taking the maximum allowable concentration (MAC) value in Poland (100 mg/m3) as the basis.
Authors:
P Kostrewski; A Wiaderna-Brycht
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  77     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Affiliation:
Department of Biological Monitoring, Institute of Occupational Medicine, Lódz, Poland.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / adverse effects,  pharmacokinetics*
Benzene Derivatives / pharmacokinetics*
Benzoates / pharmacokinetics*
Benzoic Acids*
Humans
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Benzene Derivatives; 0/Benzoates; 0/Benzoic Acids; 0/farbasol; 108-67-8/mesitylene; 499-06-9/3,5-dimethylbenzoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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