| Kinetics of dodecanedioic acid triglyceride in rats. | |
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MedLine Citation:
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PMID: 10070016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kinetics of the triglyceride of dodecanedioic acid (TGDA) has been investigated in 30 male Wistar rats after a rapid intravenous bolus injection. TGDA and its product of hydrolysis, nonesterified dodecanedioic acid (NEDA), were measured in plasma samples taken at different times using an improved high-performance liquid chromatographic method. The 24-h urinary excretion of TGDA was 1.54 +/- 0.37 micromol, corresponding to approximately 0.67% of the administered amount. Several kinetics models were considered, including central and peripheral compartments for the triglyceride and the free forms and expressing transports between compartments with combinations of linear, carrier-limited, or time-varying mechanisms. The parameter estimates of the kinetics of TGDA and of NEDA were finally obtained using a three-compartment model in which the transfer of TGDA to NEDA was assumed to be linear, through a peripheral compartment, and the tissue uptake of NEDA was assumed to be carrier limited. TGDA had a large volume of distribution ( approximately 0.5 l/kg body wt) with a fast disappearance rate from plasma (0.42 min-1), whereas NEDA had a very small volume of distribution ( approximately 0.04 l/kg body wt) and a tissue uptake with maximal transport rate of 0.636 mM/min. In conclusion, this first study on the triglyceride form of dodecanedioic acid indicates that it is rapidly hydrolyzed and that both triglyceride and nonesterified forms are excreted in the urine to a very low extent. The tissue uptake rate of NEDA is consistent with the possibility of achieving substantial energy delivery, should it be added to parenteral nutrition formulations. Furthermore, the amount of sodium administered with the triglyceride form is one-half of that necessary with the free diacid. |
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Authors:
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A de Gaetano; G Mingrone; M Castagneto; G Benedetti; A V Greco; G Gasbarrini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 276 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-15 Completed Date: 1999-04-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E497-502 Citation Subset: IM |
Affiliation:
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Biomathematics Laboratory, Consiglio Nazionale delle Ricerche, Centro Fisiopatologia Shock, Università Cattolica, 8-00168 Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Dicarboxylic Acids / metabolism* Esterification Hydrolysis Kinetics Male Models, Biological Rats Rats, Wistar Triglycerides / metabolism*, urine |
| Chemical | |
Reg. No./Substance:
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0/Dicarboxylic Acids; 0/Triglycerides; 693-23-2/dodecanedioic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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